Immer
Das beste kommt bekanntlich noch,warum nicht Südkorea.
Seoul National University
CANCER RESEARCH INSTITUTE
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¢º Cancer Vaccine
A. DNA vaccine with minimalistic expression constructs.
The low transfection efficacy obtained in large animal experiments
makes plasmid-based DNA vaccines not widely used. Another concern
is the presence of antibiotic resistance markers on virtually all
conventional plasmids. Here we describe the use of minimalistic,
immunogenically defined gene expression (MIDGE) vectors for DNA
vaccination. MIDGE are linear, covalently-closed vectors containing
all the essential information for gene expression and none of the
non-essential and potentially dangerous plasmid backbone sequences.
MIDGE vectors can also be chemically modified on both ends at
defined positions allowing targeting of the DNA to specific cell
types or cellular compartments. Immunization of mice with simple
and end-modified MIDGE vectors showed that they are efficacious
tools to generate and/or manipulate antigen-specific immune
responses.[/b]
http://cri.snu.ac.kr/aboutcri/index.asp?Action=CWK
Chul-Woo Kim, M.D., Ph.D.
Professor
Chief, Department of Pathology
Chief, Tumor Immunity MRC
Seoul National University College of Medicine
Tel: 82-2-740-8267 Fax: 82-2-3673-0662
E mail: cwkim@plaza.snu.ac.kr
Homepage: http://timrc.snu.ac.kr
Ein schönes WE,grüße Bio.