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    Diagnosis and Treatment of Breast Cancer  614  0 Kommentare EU research association proves the significance of the immune system in prognosis and treatment


    (DGAP-Media / 27.02.2015 / 15:24)

    As part of the EU RESPONSIFY research project, immune markers in tumours,
    which not only affect the prognosis of a breast cancer patient but also
    predict the response to certain treatments, were identified for the first
    time. In patients with HER2-positive or triple negative breast cancer
    (TNBC) in particular, the results of the research point the way ahead.
    These types of breast carcinomas are characterised by an aggressive
    progression of the disease, meaning that the development of new treatment
    strategies is particularly necessary for these patient groups.

    One chemotherapy option for these patients is the cytostatic drug
    Carboplatin, but this is associated with severe side effects. "The new
    markers give us the opportunity to determine for which patients Carboplatin
    actually presents a therapeutic advantage over other chemotherapy drugs.
    All other patients do not need to be subjected to the treatment and its
    additional side effects", explains Dr Sibylle Loibl, co-chair of the German
    Breast Group and scientific co-ordinator of the EU project.

    The new markers can also be used effectively as companion diagnostics in
    studies into medications that aim to strengthen the immune response to
    tumours. These new medications, which are known as immune checkpoint
    inhibitors, are currently being developed for patients whose immune systems
    are not adequately fighting the tumour cells. "The new biomarkers bring us
    a considerable step further along the path to personalised breast cancer
    medicine", says Prof. Loibl.

    The RESPONSIFY research project was thereby successfully concluded after
    three years of intensive study. The "ImmunoPredict" biomarker test is
    currently being developed for clinical practice by the company Sividon
    Diagnostics, which specialises in molecular tumour diagnostics. "Based on
    our experience, we believe that the development of the test will take
    around two years", says PD Dr Ralf Kronenwett, Head of Research and
    Development at Sividon Diagnostics. "The outstanding results of the project
    are an excellent example of transnational and inter-institutional research
    work and will have a positive impact on the diagnostics and treatment of
    breast cancer patients".

    "RESPONSIFY- Genome-based biomarkers leading to validated molecular
    diagnostic tests for response prediction in breast cancer" was sponsored by
    the EU Commission and is part of the seventh research framework programme.
    In addition to the German Breast Group and Sividon Diagnostics, nine
    further international partner institutions are working on the
    identification of biomarkers, including the Charité in Berlin, the French
    Gustave Roussy Institute, the Jules Bordet Institute in Belgium and
    University College London. The funding amount was six million EUR.


    Sividon Diagnostics GmbH was founded in July 2010 through the management
    buy-out of the company Siemens Healthcare Diagnostics Products at its
    Cologne site. The company's goal is to increase the quality of companion
    diagnostics in oncology. Sividon's first diagnostic test, the
    EndoPredict(R), has been available since 2011. The breast cancer prognosis
    test provides assistance in deciding for which patients chemotherapy is
    indicated.
    For further information, please visit www.sividon.com.


    End of Media Release

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    Issuer: Sividon Diagnostics GmbH
    Key word(s): Health

    27.02.2015 Dissemination of a Press Release, transmitted by DGAP - a
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    Media archive at www.dgap-medientreff.de and www.dgap.de

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    Diagnosis and Treatment of Breast Cancer EU research association proves the significance of the immune system in prognosis and treatment (DGAP-Media / 27.02.2015 / 15:24) As part of the EU RESPONSIFY research project, immune markers in tumours, which not only affect the prognosis of a breast cancer patient but also predict the response to certain treatments, were identified for the …