TiGenix announces launch of proposed initial public offering in the United States

PRESS RELEASE
REGULATED INFORMATION

TiGenix announces launch of proposed initial public offering in the United States

Leuven (BELGIUM) - December 5, 2016, 22:01h CET - TiGenix NV (Euronext Brussels: TIG), an advanced biopharmaceutical company focused on developing and commercialising novel therapeutics from its proprietary platforms of allogeneic expanded stem cells, announced today that it intends to offer and sell, subject to market and other conditions, 2.75 million American Depositary Shares ("ADSs") representing 55 million ordinary shares in an initial public offering in the United States (the "Offering").

In connection with the Offering, TiGenix intends to grant the underwriters a 30-day option to purchase additional ordinary shares in the form of ADSs, provided that the number of such additional ADSs shall not exceed 15% of the ADSs sold in the Offering.

Each of the ADSs offered represents the right to receive twenty (20) ordinary shares.

The final issuance price per ADS (in USD) sold in the Offering will be determined following the bookbuilding process.

TiGenix's ordinary shares are currently listed on Euronext Brussels. An application has been made to list the ADSs on the NASDAQ Global Market under the symbol "TIG". Application will also be made to admit the ordinary shares, underlying the ADSs, issued pursuant to the Offering to trading on Euronext Brussels.

BofA Merrill Lynch and Cowen and Company, LLC are acting as joint book-running managers, Canaccord Genuity is acting as lead manager and BTIG is acting as co-manager for the proposed Offering.

A registration statement has been filed with the U.S. Securities and Exchange Commission but has not yet become effective. The ADSs may not be sold nor may offers to buy be accepted prior to the time the registration statement becomes effective.

The proposed offering of ADSs will be made only by means of a prospectus. A copy of the preliminary prospectus, when available, can be obtained from BofA Merrill Lynch, NC1-004-03-43, 200 North College Street, 3rd floor, Charlotte, NC 28255-0001, Attn: Prospectus Department, Email: [e-mail] and from Cowen and Company LLC, c/o Broadridge Financial Services, 1155 Long Island Avenue, Edgewood, NY 11717, Attn: Prospectus Department, by telephone at [phone] or by fax at [phone].