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Researching the Next Generation of Products:

Nexia`s lead products are biomaterials and pharmaceuticals used to treat life-threatening disease. Nexia produces
these recombinant proteins in the milk of our transgenic BELE® goats. Nexia will further process the milk to purify
recombinant products. BioSteel® filaments are environmentally friendly and will be used in applications where
strength and flexibility are required, such as medical devices or body armour.

Corporate Offices and Research & Development Laboratory:
Nexia Biotechnologies` Corporate Offices and Research and Development facilities are located on the western tip
of the Island of Montreal, on Montreal Biotech Highway. This 11,000 square foot facility includes administrative
offices, R&D laboratories and offices for our scientists.

Molecular Biology
This area is dedicated to molecular biology and protein purification.

Cell Culture Facility
This is a clean (Class 100,000) room dedicated to cell culture technologies, including scale-up production
capabilities (ie. hollow fiber bioreactors).

Embryology
These clean rooms are equipped for microinjection, nuclear transfer and embryo culture.

Caprine Production Farm:
Nexias` Caprine production farm, Canada`s first transgenic protein production facility, was officially opened in
October, 1997. Complex II was completed in August, 1998.



Caprine Research Farm


Caprine Production Farm Overview:

Stringent criteria for site selection, including location and farming history
Canada`s first transgenic protein production facility
Complex I opened in October, 1997. (500 head)
Complex II opened in August, 1998. (500 head)
Advanced Biosecurity Zone limits disease vector intrusion
Certified scrapie-free (TSE-free) goats from New Zealand (Complex II)
High standards of animal husbandry and welfare (CCAC - compliance)
Farm management (24 hour presence) and veterinary services on site
Comprehensive health surveillance and feed and water analysis
Strict compliance with written Standard Operating Procedures (SOPs)

Caprine Breeding Farm:
located in Plattsburgh, New York part of the decommissioned Strategic Command Base


Caprine Breeding Farm:

All our production facilities:

Advanced Biosecurity Zone limits disease vector intrusion
Compliance with all Federal Regulations
Farm management (24 hour presence)
Comprehensive health surveillance and feed and water analysis
Strict compliance with written Standard Operating Procedures (SOPs)



About our Research and Development Platform
Nexia has developed a two stage integrated approach to goat transgenics which allows the company to have the
fastest program from DNA construct to recombinant proteins in milk.

The Company`s proprietary position with in vitro (MAC-T) screening methods, facilitate construct performance
evaluation. These biologically meaningful systems provide rapid screens of DNA construct integrity / function
and gene product authenticity (secretion, post-translational modifications) within ruminant mammary cells.

The large scale production of recombinant proteins is via transgenic BELE® goats. Our BELE® (Breed Early,
Lactate Early) transgenic goat system features short generation times, a multiplicity of births, lack of seasonality
and good milk production. The BELE® goat system permits rapid "access to the goat genome" on a cost/time
effective basis. Further, Nexia has a major R&D program devoted to the development and use of goat nuclear
transfer techniques as a means of improving the efficiency of gene transfer and generation of transgenic animal
founders.
 
aus der Diskussion: Nexia Biotech- große Zukunftsaussichten
Autor (Datum des Eintrages): Bombenleger  (01.12.02 13:56:42)
Beitrag: 5 von 43 (ID:7983033)
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