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United States Patent 6,551,774
West , et al. April 22, 2003

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Diagnostic methods for conditions associated with elevated cellular levels of telomerase activity


Abstract
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.


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Inventors: West; Michael D. (San Carlos, CA); Harley; Calvin B. (Palo Alto, CA); Weinrich; Scott L. (San Francisco, CA); Strahl; Catherine M. (San Francisco, CA); McEachern; Michael J. (San Francisco, CA); Shay; Jerry (Dallas, TX); Wright; Woodring E. (Arlington, TX); Blackburn; Elizabeth H. (San Francisco, CA); Kim; Nam Woo (Sunnyvale, CA); Vaziri; Homayoun (Toronto, CA)
Assignee: Board of Regents, The University of Texas System (Dallas, TX); The Regents of the University of California (Oakland, CA); Geron Corporation (Menlo Park, CA)
Appl. No.: 378535
Filed: August 20, 1999


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http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=H…


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