Sirona Biochem (Seite 1761)

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28.11.19 19:05:37
Beitrag Nr. 17.601 ()
Antwort auf Beitrag Nr.: 62.036.522 von Reini9870 am 28.11.19 16:35:32 John Bercow has described Brexit as the biggest mistake Britain has made since the second world war.
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28.11.19 19:26:49
Beitrag Nr. 17.602 ()
Antwort auf Beitrag Nr.: 62.037.866 von M@trix am 28.11.19 19:03:40Dafür verneige ich mich vor Dir!! Ein sehr feiner Zug...die OP versteht sich...
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02.12.19 09:08:04
Beitrag Nr. 17.603 ()
Sirona Biochem Reports 100% Safety in First Tox Study for Increased Concentration
of TFC-1067

Vancouver, British Columbia – December 2, 2019 – Sirona Biochem Corp. (TSX-V: SBM) (FSE: ZSB) (US-OTC: SRBCF) (“Sirona”) announces that the first toxicology test, in preparation for the new clinical study, has been completed with positive results.

In anticipation of a clinical study in Q2 of 2020, Sirona has completed the first required toxicity study for the increased dose (0.4%) of TFC-1067. The new formulation has been tested with a “cutaneous compatibility assessment” at Cosmepar in France (https://www.cosmepar.fr/en/), which is a patch on 12 subjects for a period of 48 hrs. The test is used to determine whether the formulation is an irritant to skin. TFC-1067 .4% was found to be a non-irritant in 100% of subjects in the patch test.

In a similar study[1] (published in the Annals of Dermatology 2017), 20 volunteers were patch-tested with varying levels of hydroquinone (HQ) alone and in combination with retinoic acid (RA). This combination is used in some skin lighteners to enhance the efficacy. Results of the study showed that HQ alone at 2% was an irritant in 30% of participants and up to 70% of participants at 4%. 4% is a dose often used in prescription level formulations, such as Tri-Luma[2], for melasma. In the same study, HQ combined with retinoic acid was an irritant in as many as 75% of subjects with some developing edema (inflammatory swelling of the skin). Post inflammatory responses to HQ can result in permanent discoloration to the skin.

Sirona is currently carrying out a second required tox study for TFC-1067. This study is a human repeat insult patch test (HRIPT). The HRIPT study will be 3 consecutive weeks with volunteers having repeat doses administered on a patch. Results of this study will be available early Q1 2020. Following the HRIPT, a toxicologist will examine the results for approval of the next clinical efficacy trial. Arrangements are now being made in preparation for the planned clinical trial to follow directly after the approval. We remain on target for this expedited process.

“The data we’ve received is consistent with claims that TFC-1067 is very safe at therapeutic dose. At .2% TFC-1067 was equal to HQ 2% for lightening and better than 2% hydroquinone for creating an even skin tone and we anticipate that our new dose will be more effective and quicker acting,” said Dr. Howard Verrico, CEO of Sirona Biochem. “We will not compromise on the safety of TFC-1067 as we continue to explore its full potential both in benefit to the consumer and commercial opportunity to our Sirona shareholders. It cannot be stressed enough that there is a significant unmet need for a safe alternative for people wishing to manage dark spots and create more uniform skin. There are many potentially toxic formulations available on the market that will ultimately damage the skin. Sirona Biochem will continue to strive for products that people can trust.”

The planned clinical trial is anticipated to be a value-add for the compound. Current licenses and ongoing product development by partners for TFC-1067 will not be delayed by the studies.
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02.12.19 09:30:41
Beitrag Nr. 17.604 ()
Hat daran wer noch dran gezweifelt ???? 👍👍👍🚀🚀🚀🚀🚀
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02.12.19 09:34:03
Beitrag Nr. 17.605 ()
Antwort auf Beitrag Nr.: 62.055.650 von HanfSolo am 02.12.19 09:30:41eben. Deshakb bewegt sich der Kurs auch nicht. Keine wirkliche news
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02.12.19 09:45:30
Beitrag Nr. 17.606 ()
Seeeehr schön 👌

Und alle schlafen noch 😴

Wird heute der Startschuß für einen regen Newsflow in nächster Zeit sein und einhergehend wird das All-Zeit-Hoch die nächsten 1-2 Monate in Angriff genommen...😎
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02.12.19 09:47:02
Beitrag Nr. 17.607 ()
Antwort auf Beitrag Nr.: 62.055.443 von Hydro_11 am 02.12.19 09:08:04
InflaRx kann jetzt auch über ....
...Xetra gehandelt werden!
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02.12.19 09:49:33
Beitrag Nr. 17.608 ()
alles läuft nach Plan und ist endlich auch mal im Zeitplan. Ich rechne noch mit fetten Vorweihnachtsnews. 😎✌
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1 Antwort?Die Baumansicht ist in diesem Thread nicht möglich.
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02.12.19 09:50:32
Beitrag Nr. 17.609 ()
@tom - Xetra? Wie? Was?
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02.12.19 09:54:03
Beitrag Nr. 17.610 ()
Antwort auf Beitrag Nr.: 62.055.443 von Hydro_11 am 02.12.19 09:08:04
Zitat von Hydro_11: Sirona Biochem Reports 100% Safety in First Tox Study for Increased Concentration
of TFC-1067
...
Current licenses and ongoing product development by partners for TFC-1067 will not be delayed by the studies.


Nett,
ich weiß nur von einem Partner (unterschriebener Deal).
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