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[Lemming1]

Curis and Aegera Announce Breakthrough Adult Skin-Derived Stem Cell Research Reported in September Issue of Nature Cell Biology

8/13/2001 7:16:00 AM
CAMBRIDGE, Mass. & MONTREAL, Aug 13, 2001 (BW HealthWire) --


Opens pathways to derivation of multipotent stem cells from adult skin

Curis, Inc. (CRIS) and Aegera Therapeutics Inc. today announced publication in the journal Nature Cell Biology of a breakthrough technique in stem cell research using adult human skin.

Professor Freda Miller`s findings discovered at McGill University`s Montreal Neurological Institute, Aegera`s academic collaborator, indicate that adult skin is a source of multipotent stem cells which can be directed toward neuronal or mesodermal development, including neurons, glia, smooth muscle cells and adipocytes.

Quoting from Dr. Miller`s article, "These findings indicate that adult tissues contain tissue-biased stem cells,... that may be much more `plastic` than previously appreciated... the ability to readily isolate and expand such a stem cell, from an accessible potentially autologous source such as human skin, has important therapeutic implications."

Curis, Inc. and Aegera Therapeutics Inc. entered into a licensing and research agreement in January 2001, under which Aegera granted to Curis an exclusive worldwide license on Aegera`s skin-derived, adult stem cell technologies. The agreement established a broad collaboration to investigate the therapeutic potential of these technologies in neurological, pancreatic and cardiovascular disorders. Research is to be conducted at Curis, Aegera, and McGill University`s Montreal Neurological Institute.

Doros Platika, M.D., president and chief executive officer of Curis states, "We are delighted to see confirmation of our hypothesis that stem cells present in adult skin may be able to give rise to a variety of cell types that go beyond their tissue of origin. Combining Curis` expertise in stem cells, growth factors and small molecules, with Aegera`s technology, may allow the treatment of various diseases using stem cells derived from a very accessible adult source. This will also avoid any ethical concerns surrounding the use of embryonic stem cells. The focus of our collaboration is in the field of Diabetes, Neurology and Cardiovascular medicine."

Mr. Michael Atkin, Aegera`s president commented, "Dr. Freda Miller`s dramatic proof of principle for generation of multipotent stem cells from adult skin offers hope of providing a safe, non-invasive and ethically appealing source of stem cells that our society can broadly welcome. I congratulate Dr. Miller and her team on their vision and commitment, which I believe to be equalled by our partners at Curis."


About Curis, Inc.

[Lemming1]

Vorbörslich schon über 10% im Plus!! Sieht nicht schlecht aus!

Leichte Lemming Gewinne sind möglich!!

[Lemming1]

ISLAND REAL TIME STATISTICS FOR CRIS

STATISTICS FOR CRIS
Name Curis, Inc. - Common Stock
Market NM
Last Executed Price 6.9000
Previous Closing Price 6.11
Net Change +0.7900
Percent Change +12.93%
Shares Matched 2,050
Shares Booked 61,260
Orders Booked 69
Last Trade Time 9:08:12.16
Last Order Time 9:05:53.98
Open Orders 12
LAST 20 ISLAND TRADES FOR CRIS
1. 9:08:12.16: 100 at 6.9000
2. 9:08:11.66: 100 at 6.9000
3. 9:07:54.17: 400 at 6.9000
4. 9:05:35.09: 500 at 6.9000
5. 8:57:08.91: 100 at 6.8000
6. 8:57:07.16: 600 at 6.8000
7. 8:02:23.14: 250 at 6.7500

[Lima2000]

Warum bricht das Teil in FSE bis 6€ ein???

[Richyr]

tja, wenn es an der Nasdaq runter geht, dann kann es hier nicht nach oben gehen, gut, dass ich nicht eingestiegen bin, bei 7,8 heute Mittag!

[Lemming1]

@Richyr Besser dass ich zu 7,20 gekauft habe und zu 7,90 wieder verkauft habe. Lemming Trading eben.

@Limma2000 - Hier der Grund für den Einbruch:

Curis (CRIS: news, chart, profile) fell more than 5 percent after the company said in an SEC filing late Friday that a group of stockholders, including financier Paul Allen, are selling 5.2 million shares in the medical research concern. On Friday, Curis shares sank 9.5 percent to $6.11 after the Cambridge, Mass.-based concern reported a second-quarter loss of $19.3 million, or 61 cents a share, wider than a year-ago loss of $2.5 million, or 22 cents a share. See full story.

[Lemming1]

Bin soeben wieder zu 6,0 Euro eingestiegen! Langfristig sicher guter Wert. Hier noch ein Interessanter Artikel:

By CAROLYN ABRAHAM
From Monday`s Globe and Mail


Researchers in Montreal have for the first time captured stem cells from the skin of adult mice and humans capable of growing into brain cells and a range of other tissues.

The feat offers new hope for treating neurological disorders, and comfort to U.S. President George W. Bush. Last week he set strict limits on publicly funded American research using stem cells derived from human embryos, which are destroyed when the powerful cells are extracted.

The Canadian research, published Monday in Nature Cell Biology, bolsters the view that scientists can find alternative — and less controversial — sources of stem cells, which have the unique power to divide indefinitely before growing into the various tissues and parts that constitute any living being.

The stem cells harvested at McGill University`s Montreal Neurological Institute have grown into smooth muscle cells, fat cells and brain cells — including neurons, the individual thinking units of the human mind.

"They are beautiful neurons," said molecular biologist and co-author Freda Miller. "You kind of look at them and say, this can`t be true. But then you go back and do it 10 times, and you realize it is true."

While no one yet knows if these neurons can transmit electrical and chemical signals as they do in the brain, one intriguing aspect of growing them from stem cells found in skin is that scientists could have a vast and easily accessible supply.

"It`s from skin," said Dr. Miller. "There`s so much, and it`s right there, and this is a non-controversial source."

Ronald Worton, CEO and scientific director of the Ottawa Health Research Institute and head of Canada`s Stem Cell Network, said stem cells that can produce brain cells have been found in the brain itself, but this is first time they have been grown from stem cells found in skin.

"Two years ago I would have said this is a big surprise and I wouldn`t have believed it unless it could be widely reproduced," Dr. Worton said. "But then the dogma used to be that if you were a stem cell in [adult] bone marrow, you could only make blood cells, or if you were a stem cell in skin, you only make skin. There`s now enough lab work to say the dogma was wrong."

Scientists hope to one day chemically goad stem cells into becoming replacement tissues for ailing patients, such as insulin-producing cells for diabetics, brain cells that pump out dopamine for Parkinson`s sufferers, or cells rich in dystrophin for people with muscular dystrophy.

Patients receiving new tissue grown from stem cells taken from their own skin would face far fewer problems of rejection, if any, than they would after receiving a transplant of stem cells derived from human embryos.

Dr. Miller and Jean Toma, the paper`s lead author, thought several years ago that because skin, like blood, regenerates itself on a rapid and regular basis, it could be a rich source of stem cells. In particular, they wondered about cells beneath the epidermis in the skin`s second layer, the dermis. That layer contains nerve cells that relay sensations such as touch and temperature to the brain. Since these cells regenerate after injuries such as burns or gashes, the Montreal group looked for the precursors of these sensory cells, hoping to find the stem cells that produce them.

They isolated them first in the nasal passages of mice. But the source was not practical, given the difficulty of extracting enough from a tiny, damp airway. Then they tested their hypothesis with skin from mice and from a human scalp.

They diced the skin samples and added enzymes to break down the cells and "to filter out the hair and other junk," Dr. Miller said. Next they placed the molecular mash in a tightly closed tissue-culturing flask, where the cells began to divide and grow along the electrically charged plastic bottom.

The stem cells separated from the rest of the cellular group, snuggling around one another like a cluster of grapes. After three weeks, the researchers tested their versatility by exposing them to various proteins, which encourage them to differentiate into a number of cell types.

Some of them grew into fat cells — big and round and filled with translucent bubbles. Others turned into the svelte cells of smooth muscle, which lines blood vessels and intestines. Impressively, they also blossomed into a variety of precious brain cells, including neurons, with branches sprouting across their surface to send and receive neurochemical messages, and glial cells which, among other things, produce the fatty white sheaths around nerve fibres in the brain that speed signals between neurons.

This, said Dr. Miller, is especially welcome news since these fatty sheaths are worn and frayed in patients with multiple sclerosis.

Samuel Weiss, a University of Calgary cellular biologist who first showed in the early 1990s that the adult brain of mice retains stem cells, cautioned that researchers still have to prove that stem cells from adults have long-term viability.

"We still have to answer the question as to whether or not it will be an effective treatment to replace cells," he said.

[Lima2000]

@lemming 1
thanks alot for infos,
bin seit 3er Fusion in Curis drin,denke es ist ein cooles Invest,
deren Forschung auf Knochenimplantat Ebene wird mal der Renner,
ich versteh nur nicht ob die auch inzwischen als Stammzellen-
Aktie gesehen wird??
Bushs 50%Zugeständnis war hier erst der Anfang.

Curis wird sich wieder berappeln!

lima