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ArQule *der News-Thread*



Begriffe und/oder Benutzer

 

Heißes Eisen!

Kamen gute Zahlen heute. Bin dick drin, da wird in nächster Zeit noch was gehen.
Ausbruch des Bio-Index und ArQule mit guten Zahlen!

Kann es nur weiterempfehlen!

Hier die Meldungen:

StreetInsider Alert for ARQL

Feb 12, 2004 (streetinsider.com via COMTEX) -- ArQule (Nasdaq: ARQL) reports Q4 earnings of $0.04 per share, 9 cents better than
estimates. Revenues came in at $18.4 million versus the consensus of $16.2 million. Sees 2004 revenue of $46-$48 million versus the
consensus of $52.4 million. Also announces a new agreement with Pfizer (NYSE: PFE) in which in can receive up to $184.9 million through
2008.


neue Empfehlungen:


2/12/04 - Zacks.com Announces that Lon Juricic Highlights the Following Stocks: Human Genome
Sciences, ArQule, Kosan Biosciences, and Epoch Biosciences

CHICAGO, Feb 12, 2004 (BUSINESS WIRE) -- Do a little genetic engineering on your portfolio with several biotech positions from Lon Juricic,
and learn about a company that looks ready to fulfill expectations for the future. Read about Human Genome Sciences, Inc. (NASDAQ:HGSI),
ArQule, Inc. (NASDAQ:ARQL), Kosan Biosciences Inc. (NASDAQ:KOSN), and Epoch Biosciences, Inc. (NASDAQ:EBIO). Click here for the
full story exclusively on Zacks.com: http://at.zacks.com/?id=84

Here are the highlights from the Featured Expert column:

New Position from February 9

Human Genome Sciences, Inc. (NASDAQ:HGSI) is engaged in the research and development of gene-based drugs to treat and cure disease.
Since its inception, the promise of Human Genome Sciences, a company looking to harness the power of the human genome and bring it to
the masses, has excited investors. But promises of breakthrough treatments have failed to be delivered to date.

While Lon Juricic and his team are somewhat concerned that HGSI has failed to manage Wall Street`s expectations properly, he is still very
excited about the stock. Juricic believes the second-half of 2004 thru the first-half of 2005 could be a breakthrough period for HGSI. During this
period, he expects the promises to finally start turning into realities.

Updated Position

ArQule, Inc. (NASDAQ:ARQL), is a recognized leader in small-molecule chemistry, and is pursuing a strategy to become an efficient drug
discovery and development company. One the most significant announcements for ArQule over the past few months occurred on December
19th when the company increased its expected revenues for fiscal year 2003 to reflect the meeting of certain goals in its Pfizer (NYSE:PFE)
collaboration.

Juricic and team are still very excited about ArQule, due in large part to the potential of the company`s oncology portfolio, which presently
consists of a Phase 1 clinical candidate (ARQ 501) and several discovery programs.

also, wer fährt mit Richtung Norden?

clemania
hier noch ältere Meldungen:

03.02.2004
ArQule " strong buy"
Global Biotech Investing

Die Experten vom Börsenbrief " Global Biotech Investing" stufen die Aktie von ArQule (ISIN US04269E1073/ WKN 903396) mit " strong buy"
ein.

Das Biotechunternehmen habe mit den Konzernen Bayer und Pfizer zweit große Namen an seiner Seite. ArQule forsche durch die
Kombination verschiedener Moleküle nach neuen Wirkstoffen für schwere und bis dato nur unzureichend behandelbare Krankheiten. Erste
Erfolge habe man bereits erzielen können. Der Forschungspartner Pfizer habe dem Biotechunternehmen zuletzt früher als geplant eine
Zahlung für das Erreichen erster Meilensteine geleistet.

ArQule habe daher die bisherigen Umsatz- und Ergebnisprognosen für das Geschäftsjahr 2003 nach oben nehmen können. Das
Unternehmen rechne nun mit Umätzen zwischen 63 Mio. und 65 Mio. USD und mit einem Verlust zwischen 29 und 31 Mio. USD. Bei
letzterem habe man zuvor noch ein Minus von 37 Mio. bis 39 Mio. USD erwartet. In der letzten Woche habe man die Kooperation mit Wyeth
Pharma verkünden können, was dem Unternehmen weitere Finanzmittel zufließen lasse.

Nach Erachten der Wertpapierexperten stehe ArQule, im Vergleich zu den vielen Konkurrenten aus der Branche, unmittelbar vor dem
Sprung in die Gewinnzone. Der Markt habe nun das Potenzial des Titels erkannt. Zuletzt habe die Aktie neue 52-Wochen-Hochs erzielen
können.

Die Experten vom " Global Biotech Investing" bewerten die ArQule-Aktie mit " strong buy" , bei einem Kurspotenzial von 100%. Das Stop-loss
sollte bei 3,50 EUR platziert werden.

vom 27.01.04

" Nanotech: Chance auf 100 Prozent!


Wer im Bereich Nanobiotechnologie eine weitere Ergänzung sucht, sollte sich laut „Global Biotech Daily“ einige Stücke dieses Wertes ins
Depot legen: Der Kurs der Aktie kommt erst jetzt in Fahrt und erste Erfolge zeichnen sich ab: Während Biophan sich zuletzt verdreifachte,
stieg die hier besprochene ArQule (WKN 903396) seit Dezember erst knapp 25 Prozent. ArQule hat mit Bayer und Pfizer zwei
Pharma-Riesen an seiner Seite und forscht unter Zugrundelegung der Kombination verschiedener Moleküle nach neuen Wirkstoffen gegen
schwere Krankheiten. Nach ersten Erfolgen hat Pfizer nun wesentlich früher als ursprünglich geplant eine Zahlung für das Erreichen erster
Meilensteine geleistet. Dadurch konnten die bisherigen Umsatz- und Ergebnisschätzungen für 2003 nach oben korrigiert werden. Beim
Umsatz werden nun zwischen 63 und 65 Millionen US-Dollar und beim Verlust zwischen 29 und 31 Millionen Dollar erwartet, nachdem
zuvor noch von 37 bis 39 Millionen Fehlbetrag ausgegangen worden war. Gestern meldete ArQule den Experten zufolge das Erreichen
eines weiteren Meilensteins in der Zusammenarbeit mit Wyeth Pharma. Insbesondere ist hervorzuheben, dass ArQule im Gegensatz zu
vielen anderen aus der Branche unmittelbar vor dem Sprung in die Gewinnzone steht: Ohne die Einmalbelastungen von 30,4 Millionen
Dollar für die Übernahme von Cyclis im dritten Quartal hätte das Unternehmen wohl schon per 2003 eine schwarze Null verbucht. „Global
Biotech Daily“ stuft ArQule vor den genannten Hintergründen mit einem klaren Strong Buy und einem Kurspotenzial von 100 Prozent ein. Der
Empfehlungskurs beträgt 5 Euro, bei 3,50 Euro wird zu einem Stopp-loss geraten."

http://www.boersenwelt.de/xist4c/web/27-01-04-14-18--Nanotec…

gruß an alle
clemania
noch 2 kleine Details:

aktuelle Marktkapitalisierung 175mio USD
Cash-Bestand 77mio USD

hohes Potential dürfte gegeben sein!
hmm, könnte sell on good news sein

in usa schon kurse bei 5,60....warten wirs ab.

bin mir trotzdem sicher hier ein lohnendes investment im depot zu haben.
clemania
Bin mit dabei. Wenn die Zahlen so gut sind, muss es doch nicht gleich 9% in den Keller gehen.

Kennt jemand noch weitere Gründe außer den Zahlen?

Gruß
Klr
:confused:
Naja, so toll sehen die Zahlen ja nicht aus, insbesondere die für 2004 prognostizierten, aber seht selber
Conference call scheduled for today at 9 a.m. Eastern Time
WOBURN, Mass., Feb. 12 /PRNewswire-FirstCall/-- ArQule, Inc. (Nasdaq: ARQL) today announced its financial results for the fourth quarter and year ended 2003.
For the quarter ended December 31, 2003, ArQule reported revenues of $18,443,000, compared with $16,154,000 for the same period of 2002. For the quarter, the Company reported a net loss of $5,129,000, or $0.18 per share, compared with a net loss of $59,104,000, or $2.78 per share, for the fourth quarter of 2002. The fourth quarter of 2003 net loss includes a restructuring charge of $1,529,000 related to the Company`s reassessment of its liability for its closed facility in California and a $4,750,000 loss related to a write-down of an investment in a privately-held company. The fourth quarter 2002 net loss figure includes stock-based compensation, amortization of intangibles, goodwill and intangible asset impairment charges and restructuring charges associated with the Company`s decision in December 2002 to reduce its workforce and close its facilities in California and the United Kingdom.
For the year ended December 31, 2003, ArQule`s revenues were $65,539,000, compared with revenues of $62,812,000 for the year ended December 31, 2002. The Company reported a net loss for the year ended December 31, 2003 of $34,751,000, or $1.43 per share. This compares with a net loss of $77,875,000, or $3.67 per share, for the year ended December 31, 2002. The 2003 net loss includes an in-process research and development charge related to the acquisition of Cyclis Pharmaceuticals of $30,359,000, in addition to the above-mentioned restructuring and investment write-down charges (in the aggregate, $5,989,000). The 2002 net loss figures include the effect of the above-mentioned charges.
As announced in December 2003, revenues for the fourth quarter and full year 2003 include revenues from Pfizer that had been anticipated in January 2004. These revenues were related to the achievement of certain goals and deliverables by ArQule.
ArQule ended the year with $77 million of cash and marketable securities. This figure includes a $3 million equity investment that Pfizer made in 2003 as a milestone in acknowledgement of ArQule meeting all of its 2003 deliverables.
"These results provide a very solid base on which to continue ArQule`s transition to becoming an innovative, well-financed, oncology-focused biotechnology company," said Dr. Stephen A. Hill, President and CEO of ArQule. "Our cash position at the end of 2003 will allow us to dedicate approximately $25 million per year over the next three years to our Activated Checkpoint Therapy(SM) (ACT(SM)) research and development program. This will include our lead program, ARQ 501, currently in a Phase 1 clinical trial. It will also support our multiple pipeline programs for compounds within our ACT(SM) portfolio, some of which have already commenced animal testing. As will be described below, we will continue during 2004 to strengthen our position as an effective oncology company."
Research and Development Program Update
Activated Checkpoint Therapy(SM) Platform
ArQule`s lead program, ARQ 501, is progressing according to plan. In the Phase 1 dose- escalation study, the fifth patient has been safely dosed. Dose- limiting toxicity has yet to be reached. The Company is also in the planning stage for potential new studies that would explore the effect of combinations of ARQ 501 with approved chemotherapeutic agents in specific human tumor types. The Company has increased the resources applied to its next generation of compounds directed to a number of innovative biological targets within the ACT(SM) pathways. During the course of 2004, ArQule will continue this process of reallocating resources away from some of its traditional activities in favor of greater support of its ACT(SM) research and development.
"We are delighted with the progress with ARQ 501 and very excited about our pipeline programs within the ACT(SM) platform. We have fine opportunities to further advance these programs in 2004," said Dr. Chiang Li, ArQule`s Chief Scientific Officer and Vice President, Head of ArQule`s Biomedical Institute.
Other Programs
The Company is currently exploring out-licensing opportunities for its ion channel and p38 MAP Kinase inhibitor programs. These have reached lead optimization and GLP toxicity phases, respectively. ArQule was pleased to receive a milestone payment from Wyeth on the submission of an IND derived from its Directed Array(TM) collaboration with them. A second program for which ArQule could be eligible for milestone and royalty payments continues to progress through GLP toxicity studies at Solvay.
Chemical Technologies
ArQule continues to have a productive relationship with Pfizer. In response to Pfizer`s evolving needs for chemistry support, ArQule has reduced its overall file enrichment effort and re-focused some of its resources to support rapid hit follow up. Instead of increasing its infrastructure to support the required expansion of the original agreement in subsequent years, ArQule will maintain the 2004 compound production levels for potentially the remaining term of the agreement. The revenue and expense consequences of this change are described more fully below in the Company`s 2004 guidance.
2004 Financial Guidance
As previously reported, due to the successful achievement of certain goals during 2003, payments originally anticipated from Pfizer in January 2004 were received in December 2003. In addition, the Company`s three-year, $30 million collaboration with Bayer was successfully concluded during 2003. On February 11, 2004, ArQule entered into a new agreement with Pfizer. This amends the previous collaboration agreement dated December 18, 2001. Under the terms of the amended agreement, based on the Company`s achievement of production milestones, ArQule may receive up to $184.9 million in cash from 2004 through 2008. This potentially represents a total of $291.2 million in cash for the entire collaboration, down from $345 million as previously disclosed. For 2004, expense guidance assumes a reduction in resources needed to support the Pfizer alliance, while increasing the resources available for internal research. As a consequence of the skill-set needs in discovery research, this reallocation will result in the departure of up to 55 current employees through a reduction in force now being implemented and the recruitment of a number of new employees with the skills necessary for oncology research and development activities. All costs related to this realignment are included in the Company`s expense guidance for 2004. As stated, ArQule does not anticipate a significant change to the total headcount for ArQule during 2004.
For 2004, ArQule expects revenues to range between $46 and $48 million, total cost of revenue to range between $34 and $35 million, total research and development expenses to range between $22 and $23 million and total marketing, general and administrative expenses to range between $9 and $10 million. The Company expects net investment income to range between $400,000 and $600,000. The Company expects to record a charge of between $1.2 and $1.4 million in the first quarter of 2004 associated with its decision to terminate approximately 55 employees. ArQule expects its net loss per share to range between $0.66 and $0.70 for the year. ArQule expects its net use of cash this year to range between $29 and $31 million, of which approximately $6 million will be spent on paying down debt on the building in Woburn. This guidance does not assume any additional collaborations, acquisitions or in-licensing initiatives.
"Our guidance for 2004 reflects our confidence in the strength of our oncology programs. We are well positioned to resource those programs effectively for a number of years," concluded Dr. Hill.
ArQule will hold a conference call at 9:00 a.m. Eastern Time. Dr. Stephen A. Hill, President and CEO, and Louise A. Mawhinney, CFO, will lead the call.
Date: Thursday, February 12, 2004
Time: 9:00 a.m. ET

Conference Call Numbers
Toll Free: (800) 289-0437
Toll: (913) 981-5508
Webcast: www.ArQule.com
A replay of the conference call will be available for five days and can be accessed by dialing toll-free (888) 203-1112, and outside the U.S. (719) 457- 0820. The access code is 672491.
ArQule, Inc. is a biotechnology company engaged in research and development of next-generation small-molecule cancer therapeutics based on its innovative Activated Checkpoint Therapy(SM) (ACT(SM)) platform. ACT(SM) compounds are intended to improve the way cancer patients are treated because they selectively kill cancer cells and spare normal cells by restoring and activating cellular checkpoints that are defective in cancer. The Company`s lead programs are ARQ 501 for solid cancers, presently in Phase 1 clinical trials, and ARQ 101, an optimized small-molecule compound targeting p38 MAP Kinase for rheumatoid arthritis, presently in preclinical (GLP-tox) studies. In addition to advancing its own programs, ArQule continues to advance the drug discovery efforts of pharmaceutical collaborators by providing high- quality library design and compound production. For more information about ArQule, please visit the Company`s new website at www.ArQule.com.
This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995 ("Reform Act"), which
Feb 12, 2004 (streetinsider.com via COMTEX) -- ArQule (Nasdaq: ARQL) reports Q4
earnings of $0.04 per share, 9 cents better than estimates. Revenues came in at
$18.4 million versus the consensus of $16.2 million. Sees 2004 revenue of
Also announces a new $46-$48 million versus the consensus of $52.4 million. agreement with Pfizer (NYSE: PFE) in which in can receive up to $184.9 million
through 2008


die Schulden sind drastisch reduziert worden(5Millionen nach 59 Millionen!),insbesondere wenn man bedenkt,dass 4,75 Millionen Verlust abgeschrieben werden mussten aus einem Investment in eine private Company
Und der neue Auftrag von Pfizer mit einem Volumen von 184Millionen bis 2008 geht völlig unter.
Das sind einfach nur Zocker ,die jetzt rausgehen
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