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     610  0 Kommentare RESULTS FROM THE PHASE III HERCULES STUDY OF CAPLACIZUMAB FOR THE TREATMENT OF ACQUIRED TTP SELECTED FOR PRESENTATION IN THE LATE-BREAKING ABSTRACTS SESSION AT THE 2017 ASH ANNUAL MEETING

    GHENT, Belgium, 21 November 2017 (3.30pm CET) - Ablynx NV [Euronext Brussels and Nasdaq: ABLX] today announced that results from its Phase III HERCULES study of caplacizumab have been selected as one of only six abstracts for oral presentation in the late-breaking abstracts session at the 59th Annual Meeting of the American Society of Hematology (ASH) taking place in Atlanta, GA, on 12 December 2017.

    Caplacizumab is Ablynx's wholly-owned anti-von Willebrand factor (vWF) Nanobody® being developed for the treatment of acquired thrombotic thrombocytopenic purpura (aTTP). Positive topline results from the Phase III HERCULES study, meeting primary and two key secondary endpoints, were announced on 2 October 2017.

    The abstract (LBA-1), "Results of the Randomized, Double-Blind, Placebo-Controlled, Phase III HERCULES study of Caplacizumab in Patients with Acquired Thrombotic Thrombocytopenic Purpura", will be presented by Professor Marie Scully, M.D., Department of Haematology, University College London Hospitals NHS Trust, London, UK.

    The abstract is available at https://ash.confex.com/ash/2017/webprogram/Paper109057.html and will be included in the 8 December online issue of Blood.

    Commenting on today's announcement, Dr Edwin Moses, CEO of Ablynx, said: "We are very pleased that our positive Phase III HERCULES data have been accepted for this presentation at the world's leading hematology conference, the 2017 ASH Annual Meeting in Atlanta, USA. The data confirm the significant potential of caplacizumab for patients with aTTP for whom there is currently no approved therapeutic drug available."

    Session Information

    Name: Late-Breaking Abstracts Session
    Date: Tuesday 12 December 2017   
    Time: 7:30 AM - 9:00 AM ET
    Presentation Time: 7:30 AM ET
    Room: Building C, Level 1, Hall C2-C3 (Georgia World Congress Center) 

    About HERCULES

    The HERCULES study recruited 145 patients and is the largest randomised, double-blind, placebo-controlled study conducted in patients with aTTP. Patients with an acute episode of aTTP were randomised 1:1 to receive either caplacizumab or placebo in addition to daily plasma exchange (PEX) and immunosuppression. Patients received a single intravenous bolus of 10mg caplacizumab or placebo followed by a daily subcutaneous dose of 10mg caplacizumab or placebo for 30 days after the last daily PEX. If at the end of this treatment period there was evidence of persistent underlying disease activity (indicative of an imminent risk for recurrence), treatment could be extended for additional seven-day periods up to a maximum of 28 days and was to be accompanied by optimisation of immunosuppression. Patients were followed for a further 28 days after discontinuation of treatment.

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    RESULTS FROM THE PHASE III HERCULES STUDY OF CAPLACIZUMAB FOR THE TREATMENT OF ACQUIRED TTP SELECTED FOR PRESENTATION IN THE LATE-BREAKING ABSTRACTS SESSION AT THE 2017 ASH ANNUAL MEETING Ablynx NV [Euronext Brussels and Nasdaq: ABLX] today announced that results from its Phase III HERCULES study of caplacizumab have been selected as one of only six abstracts for oral presentation in the late-breaking abstracts session at the …