Transparency notifications pursuant to Article 14 of the Law of May 2, 2007

REGULATED INFORMATION
PRESS RELEASE

Transparency notifications
pursuant to Article 14 of the Law of May 2, 2007

Leuven (Belgium) - January 12, 2018, 22:00h CET - TiGenix NV (Euronext Brussels and Nasdaq: TIG; "TiGenix") announced today that it received transparency notifications pursuant to Article 14 of the Belgian Law of May 2, 2007 regarding the publication of major holdings in issuers whose securities are admitted to trading on a regulated market and including various provisions.

Summary of the notifications

It concerns the following four notifications:

• On January 8, 2018, TiGenix received a transparency notification from Philippe ODDO, following the acquisition of voting securities or voting rights on January 5, 2018, after which Philippe ODDO (through its subsidiary ODDO BHF ASSET MANAGEMENT SAS) holds 8,723,784 voting rights in TiGenix (3.18% of the total number of voting rights). As a result the 3% threshold was crossed.
   
• On January 10, 2018, TiGenix received a transparency notification from Melqart Asset Management LP, following the acquisition of financial instruments that are treated as voting securities on January 5, 2018, after which Melqart Asset Management LP (through its subsidiary Melqart Asset Management (UK) Ltd) holds 12,870,000 voting rights in TiGenix that may be acquired if the instrument is exercised (4.69% of the total number of voting rights). As a result the 3% threshold was crossed.
   
• On January 10, 2018, TiGenix received a joint transparency notification from Takeda Pharmaceutical Company Limited and Grifols, S.A., following the conclusion of an agreement to act in concert on January 5, 2018, after which Takeda Pharmaceutical Company Limited and Grifols, S.A. (through their respective subsidiaries Takeda Pharmaceuticals International AG and Gri-Cel, S.A. and Grifols Worldwide Operations Ltd) jointly hold 51,079,756 voting rights in TiGenix (18.62% of the total number of voting rights). As a result the 15% threshold was crossed.
   
• On January 10, 2018, TiGenix received a transparency notification from JPMorgan Chase & Co., following the acquisition of voting securities or voting rights on January 5, 2018, after which JPMorgan Chase & Co. (through its subsidiary J.P. Morgan Securities LLC) holds 9,201,927 voting rights in TiGenix (3.35% of the total number of voting rights). As a result the 3% threshold was crossed.

1. Content of the notification by Philippe ODDO