New Data Show That High Quality Cleansing Improves Lesion Detection During Colonoscopy Compared to Adequate Cleansing[i]

AMSTERDAM, April 21, 2018 /PRNewswire/ --

Norgine B.V. today announced new data showing that there is a strong correlation between higher cleansing scores and increased polyp detection rate (PDR) and adenoma detection rate (ADR).

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The adenoma detection rate (ADR) is one of the primary quality measures of colonoscopy and an indicator of the likelihood of subsequent patient colorectal cancer.

The data were presented at the European Society for Gastrointestinal Endoscopy (ESGE) 2018, oral presentation, OP251, 21 April 2018, 11:36 to 11:48 am.

This post hoc analysis determined the relationship between BBPS* scores and adenoma and polyp detection rates in patients who had identical scores in each of the three colon segments, using pooled data from three similarly designed Phase 3, multicentre, randomised trials: NOCT, MORA and DAYB.

       Overall colon                                             High-       Odds ratio
       lesion                                                   Quality:      Adequate :
       detection         High-        Adequate    Low-Quality   Adequate     Low-Quality
       rates                                                    (95% CI)      (95% CI)
                     Quality(N=166)    (N=950)      (N=54)
                                                                [P-value]     [P-value]

                                                                     1.60          0.90
                                                               (1.14-2.24)   (0.50-1.60)
       PDR, n (%)      91 (54.8)      396 (41.7)   22 (40.7)      [0.0067]      [0.7104]

                                                                     1.97          0.75
       ADR, n (%)      71 (42.8)      247 (26.0)   15 (27.8)   (1.39-2.80)   (0.39-1.43)
                                                                  [0.0001]      [0.3829]
      LR Analysis
               of
      Association
          between                                    0.0239
     Uniform BBPS
      Score Group
         and PDR,
          P-value

      LR Analysis
               of
      Association
          between                                    0.0006
     Uniform BBPS
      Score Group
         and ADR,
          P-value