Kyowa Kirin Presents Data at EORTC-Cutaneous Lymphoma Task Force Meeting Showing Significantly Improved Quality of Life for Patients With Mycosis Fungoides (MF) and Sézary Syndrome (SS) on Mogamulizumab

TOKYO, September 28, 2018 /PRNewswire/ --

First oral presentation of Quality of Life data from the phase III trial (MAVORIC), the largest randomised trial in MF and SS - the two most common types of Cutaneous T Cell Lymphoma^[1] 

Kyowa Hakko Kirin Co., Ltd., (Kyowa Kirin) announces that Quality of Life (QoL) data from the pivotal MAVORIC trial will be the subject of an oral presentation,^[2] at the European Organization for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Task Force (CLTF) meeting, September 27-29, St. Gallen, Switzerland. A case report of a long-term responder in the MAVORIC^[3] trial will also be reported as a poster.^[4]

Presentation titles at the 2018 EORTC CLTF Mtg: 

• Quality of Life in Cutaneous T Cell Lymphoma Patients Treated with the Anti-CCR4 Monoclonal Antibody Mogamulizumab Versus Vorinostat: Results from MAVORIC
  [Abstract 105; Fri 28^th Sept, 11am-12.30pm]
• Long-term complete remission induced by mogamulizumab in a severe Sezary patient, together with five different possible autoimmune manifestations
  [Abstract #059; Case study poster (external)]

QoL was a secondary end-point of the phase 3 MAVORIC (mogamulizumab versus vorinostat in previously treated cutaneous T-cell lymphoma) trial and significant improvements were seen with mogamulizumab versus vorinostat as early as cycle three and continued throughout. Using QoL measurements including Skindex-29, Functional Assessment of Cancer Therapy-General (FACT-G) and EuroQol-5D-3L (EQ-5D-3L), clinically meaningful improvements in patient-reported skin-related symptoms and preservation of physical well-being were observed. ≥ 61% of mogamulizumab patients reported clinically-meaningful improvements in skin-related symptoms from Cycles 3 through to 11 and significantly more vorinostat patients reported clinically-meaningful declines in physical well-being in Cycles 1 through to 11. There was also delay in patient reported deterioration in the Skindex-29 Summary and Emotions subscores in patients given mogamulizumab.

Dr Pierluigi Porcu, Sidney Kimmel Cancer Center at Jefferson Health, Thomas Jefferson University, USA elaborates further on the data: "Cutaneous T cell lymphomas are highly visible cancers, that can significantly impact patients' QoL. The effects of the disease can be extremely debilitating, which in turn can affect the patient both mentally and emotionally. We are extremely excited about these findings as it demonstrates the potential benefits of mogamulizumab beyond efficacy and, in particular, for outcomes that are especially important to people affected by CTCL. It is reassuring to see quick improvements and benefits across Symptom, Emotional, and Functional domains. Importantly, patients with the highest symptom burden and functional impairment derived the most QoL benefit from mogamulizumab."