ACADIA Pharmaceuticals to Present Phase 2 CLARITY Results for Pimavanserin as an Adjunctive Treatment in Major Depressive Disorder at the 2019 American Psychiatric Association Annual Meeting

ACADIA Pharmaceuticals Inc. (Nasdaq: ACAD), a biopharmaceutical company focused on the development and commercialization of innovative medicines to address unmet medical needs in central nervous system disorders, today announced it will present data from its Phase 2 CLARITY study, which evaluated the efficacy, safety, and tolerability of pimavanserin as an adjunctive treatment for major depressive disorder (MDD) at the 2019 American Psychiatric Association Annual Meeting in San Francisco, May 18 – 22, 2019.

Poster Presentation
Poster: #P8-049
Date/Time: Tuesday, May 21, 2:00 p.m. – 4:00 p.m. Pacific Time
Title: CLARITY: A Phase 2 Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorder

The Phase 2 CLARITY study was a 10-week, randomized, double-blind, placebo-controlled, multi-center, two-stage sequential parallel comparison design study that evaluated the efficacy, safety, and tolerability of pimavanserin (34 mg once daily). Pimavanserin was administered as an adjunctive treatment in patients with MDD who had an inadequate response to a stable dose of standard antidepressant therapy with either a selective serotonin reuptake inhibitor (SSRI) or a serotonin norepinephrine reuptake inhibitor (SNRI). The study randomized 207 patients across 27 clinical research centers in the U.S. and was conducted in collaboration with the Massachusetts General Hospital (MGH) Clinical Trials Network and Institute.

“There is a significant need for new therapies for the majority of patients suffering from major depressive disorder who do not respond to initial antidepressant therapy,” said Professor Maurizio Fava, M.D., Executive Vice Chair, Department of Psychiatry, MGH, Director of the Division of Clinical Research of the MGH Research Institute, and Associate Dean for Clinical & Translational Research, Harvard Medical School. “The results observed in the Phase 2 CLARITY study combined with a favorable tolerability profile provides evidence that adjunctive treatment with pimavanserin may provide meaningful benefit to those MDD patients who have an inadequate response to either a SSRI or a SNRI therapy.”