BioArctic and Eisai Present New Data Regarding BAN2401 at the Alzheimer's Association International Conference 2019

STOCKHOLM, July 18, 2019 /PRNewswire/ -- BioArctic AB (publ) (Nasdaq Stockholm: BIOA B) announces that new data related to BAN2401 were presented on July 17. The presentations were held by BioArctic and its partner, Eisai, at the Alzheimer's Association International Conference 2019 (AAIC) in Los Angeles, USA. BAN2401 was designed and generated to selectively target toxic protofibrils and oligomers, soluble aggregated forms of amyloid beta. The new data included details of the binding profile of BAN2401 and additional analyses from the earlier presented Phase 2b study in 856 patients with early Alzheimer's disease. All data were consistent with previously presented outcomes from the Phase 2b study.

BioArctic presented new data around BAN2401's binding profile. The new data confirmed BAN2401's strong binding and high selectivity for protofibrils and oligomers. The poster presentation can be found on BioArctic's website at www.bioarctic.com.  

Eisai presented data on biomarkers of neurodegeneration (cerebral spinal fluid, or CSF, biomarkers), which suggested that treatment with BAN2401 in patients with early Alzheimer's disease was associated with reduced neurodegeneration at both 12- and 18-months timepoints. CSF biomarker data shows the impact downstream of the amyloid cascade, including a reduction of tau pathology (p-tau) and synaptic function (neurogranin), and a reduction in the increase of axonal degeneration (neurofilament light chain or NfL). These analyses were conducted with a subset of patients from the Phase 2b study where cerebral spinal fluid samples were collected. The findings are consistent with the previously presented positive effects on cognition and on reduction of amyloid beta in the brain with PET imaging.

Further, it was observed that the positive impact on neurodegenerative biomarkers was more pronounced in patients who are ApoE4 carriers. This finding is also is consistent with the previously announced results for ApoE4 carriers on cognition and reduction of amyloid beta in the brain with BAN2401.

Eisai also presented new data that showed a positive correlation between clinical cognition endpoints and reduction of amyloid beta in the brain after both 12- and 18-months treatment. The analysis was conducted comparing the clinical endpoints ADCOMS, ADAS-Cog and CDR-SB with two approaches to analyze the reduction of amyloid beta in the brain with PET imaging. The subset of patients included in this analysis had assessments from both from the clinical endpoints and PET imaging in the Phase 2b study in early Alzheimer's disease.