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Oncopeptides Announces Acceptance of Data for Presentation at International Myeloma Workshop, September 12-15

Nachrichtenquelle: PR Newswire (engl.)
16.08.2019, 22:20  |  535   |   |   

STOCKHOLM, Aug. 16, 2019 /PRNewswire/ -- Oncopeptides AB (Nasdaq Stockholm: ONCO) announced today the acceptance of an oral late breaking presentation providing updated melflufen data from the Phase 2 pivotal OP-106 HORIZON study as well as two poster presentations at the 17th International Myeloma Workshop (IMW) meeting (September 12-15, Boston, Massachusetts, USA).

Melflufen is a lipophilic peptide-conjugated alkylator belonging to a novel class of Peptidase Enhanced Cytotoxics (PEnC) and is presently being evaluated in a broad global clinical development program.

Comment from CEO Jakob Lindberg
"We are looking forward to the upcoming IMW meeting.  IMW is an important myeloma-specific meeting held every two years.  Professor Paul G. Richardson will be presenting data from the phase 2 HORIZON study at the oral late breaking session on melflufen's activity in patients with relapsed-refractory multiple myeloma (RRMM) and extra medullary disease (EMD).  At the European Hematology Association (EHA) in June, interim data were presented suggesting that melflufen may be the first drug to exhibit meaningful activity in this difficult to treat EMD patient population. To our knowledge, HORIZON represents the largest clinical trial cohort of EMD patients to date and there is a clear unmet medical need in this rapidly growing patient population" said Jakob Lindberg, CEO Oncopeptides. "Melflufen, in combination with dexamethasone, demonstrates encouraging activity in advanced RRMM patients with EMD. Response rates appear higher than observed in prior studies and this could be linked to melflufen's unique mechanism of action. These results are encouraging, and we continue to monitor this patient group in ongoing and future clinical trials". 

Upcoming presentations at IMW
The HORIZON data will be presented as an oral presentation by Professor Paul G. Richardson, in the plenary session "Late Breaking Abstracts" on Sunday, September 15 at 08.30 AM (ET) (14.30 CET) under the title: Activity of Melflufen in RRMM Patients with Extramedullary Disease in the Phase 2 HORIZON Study (OP-106) – Promising Results in a High-Risk Population.

The first poster presentation will be held during Poster Session I, Multiple Myeloma Genomics – Friday, September 13 at 6.30 – 8.00 PM (ET) (Saturaday, September 14 at 00.30 - 02.00 CET) under the title: Aminopeptidase gene expression in myeloma.

The second poster presentation will be held during Poster Session II, Treatment of Previously Treated Myeloma – Saturday, September 14 at 12.30 – 2.00 PM (ET) (18.30 - 20.00 CET) under the title: Quality of life treatment for relapsed/refractory multiple myeloma, a systematic review.

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