Arrowhead Pharmaceuticals Presents Initial Top-Line Clinical Data and Preclinical Data on RNAi Candidates ARO-APOC3 and ARO-ANG3
Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) today presented initial top-line clinical data at The Global Summit on Cardiology and Heart Diseases, being held in Dubai, UAE. The data demonstrate that, in two Phase I single-dose clinical studies in healthy volunteers, ARO-APOC3 reduced plasma Apolipoprotein C-III (apoC-III) and ARO-ANG3 reduced plasma angiopoietin like protein 3 (ANGPTL3), and both candidates reduced triglycerides without drug-related serious or severe adverse events. These initial clinical data also indicate that ARO-APOC3 and ARO-ANG3 administration led to a long duration of effect that potentially enables once every three-month or once every six-month dosing intervals.
Bruce Given, M.D., chief operating officer and head of R&D at Arrowhead, said: “The results presented today at The Global Summit on Cardiology and Heart Diseases suggest that Arrowhead’s RNAi-based cardiometabolic candidates, ARO-APOC3 and ARO-ANG3, hold significant promise for the treatment of patients with hypertriglyceridemia and dyslipidemia. Our clinical and preclinical data clearly show that both ARO-APOC3 and ARO-ANG3 are highly active against their respective targets and lipid parameters. In addition, there is encouraging evidence from genetic studies, preclinical studies, and proof of concept from other drug candidates that inhibiting apoC-III and ANGPTL3 has the potential to help patients with rare diseases, such as familial chylomicronemia syndrome (FCS) and homozygous familial hypercholesterolemia (HoFH), as well as individuals with higher prevalence cardiovascular and metabolic diseases. Achieving deep reductions in plasma triglycerides of 66% and 63% after only a single dose of ARO-ANG3 and ARO-APOC3, respectively, exceeded our expectations. These data compare quite favorably with clinical data from other modalities, including antibodies and antisense, which we include as reference in the backup slides of the presentation available on the Events and Presentations page under the Investors tab on our website. We look forward to sharing a fuller dataset, including a broader set of lipid parameters and full time course from the single ascending dose portions of the ARO-APOC3 and ARO-ANG3 Phase 1 studies in healthy volunteers later this year and the multiple ascending dose portions in various patient populations as data mature.”