Deciphera Pharmaceuticals to Present Data Updates From Portfolio of Kinase Switch Control Inhibitors in Four Poster Sessions at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

Deciphera Pharmaceuticals, Inc. (Nasdaq:DCPH), a clinical-stage biopharmaceutical company addressing key mechanisms of tumor drug resistance, today announced that data from four of the Company’s pipeline programs will be presented in poster sessions at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics to be held October 26-30, 2019 in Boston, MA.

A copy of each abstract will be available via the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics website.

Details of the four poster sessions are as follows.

Poster Title: Phase 1b/2 study of rebastinib (DCC-2036) in combination with paclitaxel: preliminary safety, efficacy, pharmacokinetics and pharmacodynamics in patients with advanced or metastatic solid tumors
Session Title: Immune Modulators
Author: Filip Janku, MD, University of Texas MD Anderson Cancer Center
Session Date and Time: Monday, October 28, 12:30-4:00 PM ET
Location: Hall D, Hynes Convention Center
Abstract Number: B055

Poster Title: Preclinical studies with DCC-3116, an ULK kinase inhibitor designed to inhibit autophagy as a potential strategy to address mutant RAS cancers
Session Title: New Molecular Targets
Author: Bryan D. Smith, PhD, Deciphera Pharmaceuticals
Session Date and Time: Monday, October 28, 12:30-4:00 PM ET
Location: Hall D, Hynes Convention Center
Abstract Number: B129

Poster Title: Updated results of phase 1 study of ripretinib (DCC-2618), a broad-spectrum KIT and PDGFRA inhibitor, in patients with gastrointestinal stromal tumor (GIST) by line of therapy (NCT02571036)
Session Title: Therapeutic Agents: Small Molecule Kinase Inhibitors
Author: Ping Chi, MD, PhD, Memorial Sloan Kettering Cancer Center
Session Date and Time: Tuesday, October 29, 12:30-4:00 PM ET
Location: Hall D, Hynes Convention Center
Abstract Number: C077

Poster Title: Phase 1 study of DCC-3014, an oral inhibitor of CSF1R, to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics in patients with advanced solid tumors, including diffuse-type tenosynovial giant cell tumor
Session Title: Therapeutic Agents: Small Molecule Kinase Inhibitors
Author: Matthew H. Taylor, MD, Oregon Health & Science University
Session Date and Time: Tuesday, October 29, 12:30-4:00 PM ET
Location: Hall D, Hynes Convention Center
Abstract Number: C087

About Ripretinib

Ripretinib is an investigational tyrosine kinase switch control inhibitor that was engineered to broadly inhibit KIT and PDGFRα mutated kinases by using a unique dual mechanism of action that regulates the kinase switch pocket and activation loop. Ripretinib is currently in clinical development for the treatment of KIT and/or PDGFRα-driven cancers, including gastrointestinal stromal tumors, or GIST, systemic mastocytosis, or SM, and other cancers. Ripretinib inhibits initiating and secondary KIT mutations in exons 9, 11, 13, 14, 17, and 18, involved in GIST, as well as the primary D816V exon 17 mutation involved in SM. Ripretinib also inhibits primary PDGFRα mutations in exons 12, 14 and 18, including the exon 18 D842V mutation, involved in a subset of GIST. In June 2019, the U.S. FDA granted Fast Track Designation to ripretinib for the treatment of patients with advanced GIST who have received prior treatment with imatinib, sunitinib and regorafenib.