CytoDyn Announces CROI’s Acceptance of Late-Breaking Abstract by Dr. Jonah Sacha for use of Leronlimab as PrEP

Acceptance underscores the scientific community’s recognition of leronlimab as a potential HIV prophylactic

CytoDyn is currently partnered with the Thai Red Cross AIDS Research Centre (TRCARC) to develop and conduct clinical trials evaluating the potential of leronlimab to prevent HIV; trial could begin this year

VANCOUVER, Washington, Jan. 27, 2020 (GLOBE NEWSWIRE) -- CytoDyn Inc. (OTC.QB: CYDY), (“CytoDyn” or the “Company”), a late-stage biotechnology company developing leronlimab (PRO 140), a CCR5 antagonist with the potential for clinical indications in HIV, cancer, GvHD and NASH, announced today the acceptance of a late-breaking abstract that will be presented at the Conference on Retroviruses and Opportunistic Infections (CROI) to be held on March 8-11, 2020 in Boston. Poster presentations will detail the results from a preclinical study demonstrating that leronlimab prevented intrarectal transmission of Simian-Human Immunodeficiency Virus (SHIV) in macaques. These data support the potential of leronlimab as a pre-exposure prophylaxis (PrEP) treatment option.

Details of the presentation are as follows:

Presentation Title: CCR5 antibody blockade protects macaques from intrarectal SHIV acquisition
Presenter: Dr. Jonah Sacha, Ph.D., Professor at the Vaccine and Gene Therapy Institute at the Oregon Health & Science University and senior science advisor to CytoDyn
Presentation Date and Time: March 9, 2020 from 2:30 p.m. ET – 4:00 p.m. ET
Location: Hynes Convention Center, Boston, MA

Additional details can be found on the conference website.

Dr. Jonah Sacha stated, “In the absence of a prophylactic vaccine, the use of antiretroviral medications as pre-exposure prophylaxis (PrEP) to prevent HIV acquisition by uninfected individuals is a promising approach to slowing the epidemic. Unfortunately, negative side effects, viral resistance, and regimen adherence severely limit PrEP efficacy. Therefore, the development of new, highly effective, and long-acting PrEP modalities with high patient uptake is urgently needed. The positive results reported here in the pre-clinical macaque model of HIV sexual transmission are exciting given the potential for immediate clinical translation.”