Sanofi to present growth opportunities and development strategy for Dupixent (dupilumab) in type 2 inflammatory diseases

Sanofi to present growth opportunities and development strategy for Dupixent (dupilumab) in type 2 inflammatory diseases

• Additional data contribute to the growing body of evidence demonstrating Dupixent’s best in class safety profile combined with strong efficacy benefit for atopic dermatitis and further validate it as a standard of care treatment for asthma
• Dupixent’s unique mechanism of action simultaneously inhibits IL-4 and IL-13, which play a key role in type 2 inflammation in multiple diseases
• Recent evidence further supports additional clinical uses in diseases driven by type 2 inflammation including Eosinophilic Esophagitis and a subset of Chronic Obstructive Pulmonary Disease

PARIS – June 11, 2020 – Sanofi commercial and R&D executives will provide an overview of the growth and development strategy for Dupixent (dupilumab)  in the third of its five-part series to highlight Sanofi’s progress in R&D. As announced in December 2019, Sanofi expects to deliver strong growth for Dupixent with the ambition of achieving more than €10 billion in peak sales driven by its selective mechanism of action targeting the type 2 inflammation pathway. Sanofi co-develops and co-commercializes Dupixent with Regeneron.

“By specifically targeting IL-4 and IL-13, Dupixent’s mechanism of action is uniquely suited to help address conditions driven by type 2 inflammation,” said John Reed, M.D., Ph.D., Global Head of Research and Development, Sanofi. “While atopic dermatitis and asthma are the foundational diseases where Dupixent was first approved for use, great opportunity exists across multiple diseases where type 2 inflammation plays a role. We are therefore aggressively pursuing clinical evaluation of additional indications where patients are urgently awaiting solutions for their unmet medical needs.”

Today’s presentation will detail five potential future line extensions for Dupixent, including:

      · Eosinophilic Esophagitis (EoE) – It was recently announced that Part A of the Dupixent EoE pivotal Phase 3 trial met both co-primary endpoints as well as all key secondary endpoints. Dupixent demonstrated significant clinical and anatomic improvements, including the ability to swallow. In the U.S., approximately 160,000 patients with EoE are currently treated, of which an estimated 50,000 have failed multiple treatments.