Zealand Pharma presents elaborated results on the use of regular human insulin delivered by V-Go in older adults with type 2 diabetes, at the 80th Scientific Sessions of the American Diabetes Association

Press release – No. 08 / 2020

Zealand Pharma presents elaborated results on the use of regular human insulin delivered by V-Go in older adults with type 2 diabetes, at the 80^th Scientific Sessions of the American Diabetes Association

• In older adults with type 2 diabetes, use of human regular insulin delivered by V-Go demonstrated similar glycemic control with no increased hypoglycemia risk compared to use of rapid acting insulin analogs
   
• The use of U-100 Regular Human Insulin with V-Go Wearable Insulin Delivery device has not yet been cleared by the Food and Drug Administration or European Union

Copenhagen, June 13, 2020 – Zealand Pharma A/S (Nasdaq: ZEAL) (CVR-no. 20045078), a biotechnology company changing lives with innovative peptide-based medicines, presented during the 80^th Scientific Sessions of the American Diabetes Association (ADA) two elaborated results from a 14-week multi-center randomized, parallel trial comparing safety and clinical outcomes between the use of human regular insulin (HRI) compared to rapid acting insulin (RAI) when delivered by V-Go in adults with type 2 diabetes. For more information, visit https://www.clinicaltrials.gov/ct2/show/NCT01326598. The scientific sessions were held as a virtual meeting June 12-16, 2020.   

Dr. Pablo F Mora, Endocrinologist, Dallas Diabetes Research Center, Dallas, Texas presented a poster entitled Comparison of Hypoglycemia Safety between U-100 Human Regular Insulin and Rapid Acting Insulin Delivered by V-Go Wearable Insulin Delivery in Type 2 Diabetes (Abstract number: 1005-P). This analysis comprised an extensive review of the hypoglycemia safety data from the full study population (N=136) and suggests that in a Type 2 Diabetes population, the risk of hypoglycemia is not increased when using HRI compared to RAI in V-Go.    

In a second poster presentation based on the same 14-week study, Dr. David R Sutton, Endocrinologist, Northeast Florida Endocrine and Diabetes Associates, Jacksonville, Florida, presented the Efficacy and Safety Comparison between U-100 Human Regular Insulin and Rapid Acting Insulin when Delivered by V-Go Wearable Insulin Delivery in an Older Type 2 Diabetes Population, (Abstract number: 987-P). This post-hoc exploratory analysis in fifty-three subjects evaluated the clinical and safety outcomes between the use of HRI and RAI delivered by V-Go in an adult population 65 years of age or older. Findings suggest non-inferiority for change in overall blood sugar (A1C) and similar hypoglycemia event rates between the groups when switching from RAI to HRI.