Allogene Therapeutics Announces Publication Highlighting Potential for ALLO-819 In Acute Myeloid Leukemia
- FLT3-Directed AlloCAR T Therapy Demonstrated Potent Anti-Leukemic Activity in Pre-Clinical Models Without Evidence of Off-Target Activity
SOUTH SAN FRANCISCO, Calif., June 22, 2020 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) therapies for cancer, today announced a publication in Molecular Therapy demonstrating the potential for ALLO-819, an investigational AlloCAR T therapy targeting FLT3 as a novel treatment for acute myeloid leukemia (AML). These preclinical findings were previously presented as a poster at the 61st American Society of Hematology (ASH) Annual Meeting & Exposition in December 2019.
“While we’ve seen exceptional clinical efficacy with autologous CAR T therapies in hematological malignancies, the inherent limitations of autologous cell therapies can be more pronounced in a rapidly progressing disease such as advanced AML,” said Barbra Sasu, Ph.D., Chief Scientific Officer at Allogene. “The high anti-leukemic activity of ALLO-819 seen in preclinical studies, combined with a safety mechanism to mitigate potential off-tumor effects and the benefits of an off-the-shelf option, supports our goal to advance ALLO-819 for a patient population with very few treatment options.”
In this study, healthy donor T lymphocytes were engineered to express CARs that bound to different domains of the FLT3 protein. These CARs were then tested for their ability to mediate specific killing of FLT3-expressing cells without off-target activity. A CAR construct was selected based on exhibiting minimal potential for exhaustion and potent antitumor activity in vitro and in vivo models.The lead candidate was then engineered to contain an off-switch responsive to rituximab, resulting in ALLO-819.
ALLO-819 utilizes Cellectis technologies. Allogene holds global development and commercial rights for this investigational candidate. This pre-clinical research was conducted in collaboration with both Cellectis and Pfizer Cancer Immunology Discovery.
About Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a form of cancer that is characterized by infiltration of the bone marrow, blood, and other tissues by proliferative, clonal, abnormally differentiated, and occasionally poorly differentiated cells of the hematopoietic system.i AML is the second most common type of leukemia diagnosed in adults and children, but most cases occur in adults, making up 32% of all adult leukemia cases.ii Patients with relapsed or refractory AML often have a poor prognosis and limited treatment options, and is typically only curable in 5 to 15% of patients who are older than 60 years of age.iii
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