TFF Pharmaceuticals Comments on Animal Studies in the Development of High Potency Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing - Seite 2
“This significant new in vitro research continues to build and advance the seminal work done earlier by Dr. Williams and his team on reformulating remdesivir using our Thin Film Freezing technology,” said Glenn Mattes, President and CEO of TFF Pharmaceuticals. “This study developed significant new data on the delivery of high drug loads of remdesivir and its active form to the lungs, as well as confirmed the important temperature stability benefits that Thin Film Freezing imparts on drug formulations, a potentially key factor in future vaccine delivery efforts.”
“Since remdesivir is a poorly water-soluble drug, its dissolution may be a critical factor in the drug’s release in the lung fluid, especially in high drug load formulations. Our data indicates that dry powder administration can deliver high potency remdesivir to the lungs, which is then converted to its nucleoside analog GS-441524 at the target site before entering the system circulation,” said Robert O. Williams III, study co-author. “And importantly, new data from the study regarding the formulation of remdesivir with leucine suggest that the TFF formulation can significantly prolong the duration of the remdesivir nucleoside analog GS-441524 in the lung, providing a important therapeutic benefit for lung delivery.”
“This is vital work being pursued by Dr. Williams and his team, as it potentially brings us closer to the day when this treatment could be administered to patients earlier in the disease, directly to site of initial infection and in a convenient and accessible dosage form that could be administered outside of a hospital setting” said Mattes. “It’s another real-world demonstration of the ability of our Thin Film Freezing platform to adapt to a variety of compounds that may be poorly water soluble and thus may be challenging to deliver therapeutically.”
“Remdesivir is the proprietary product of Gilead and, at this time, TFF has no agreements with Gilead concerning a collaboration built around remdesivir and our TFF platform,” said Mattes. “And while we intend to pursue meaningful discussions with Gilead regarding the results of Dr. Williams’ growing dossier of formulation work, there can be no assurance that this effort would result in a collaboration between our companies.”
About TFF Pharmaceuticals’ Thin Film Freezing technology platform
TFF Pharmaceuticals’ Thin Film Freezing (TFF) platform was designed to improve the solubility and absorption of poorly water-soluble drugs and is particularly suited to generate dry powder particles with properties targeted for inhalation delivery, especially to the deep lung, an area of extreme interest in respiratory medicine. The TFF process results in a “Brittle Matrix Particle,” which possesses low bulk density, high surface area, and typically an amorphous morphology. allowing the particles to supersaturate when contacting the target site, such as lung tissue. Based upon laboratory experiments the aerodynamic properties of the particles are such that the portion of a drug deposited to the deep lung has the potential to reach as high as 75 percent.