Apellis to Present Positive Results from the Phase 2 DISCOVERY Study of Pegcetacoplan in C3 Glomerulopathy (C3G) at ASN Kidney Week - Seite 2

Presentation Details at ASN Kidney Week 2020

C3 Inhibition with Pegcetacoplan Targets the Underlying Disease Process of C3 Glomerulopathy (C3G) and Improves Proteinuria, ePoster # PO1852 – Oct. 22 at 10:00 a.m. ET.

About the DISCOVERY Study
The DISCOVERY study is a Phase 2, open-label trial designed to evaluate the preliminary efficacy and safety of pegcetacoplan in patients with complement-driven renal diseases. Eight C3G patients were enrolled into the study. Three patients were excluded from the analysis at 48 weeks due to self-reported non-compliance or study drug interruption.

The primary endpoint in the DISCOVERY study is change from baseline in proteinuria at week 48 as measured by 24-hour urine protein-to-creatinine ratios (uPCR). Secondary endpoints include analysis of serum C3 and estimated glomerular filtration rate (eGFR).

About Pegcetacoplan (APL-2)
Pegcetacoplan is an investigational, targeted C3 therapy designed to regulate excessive complement activation, which can lead to the onset and progression of many serious diseases. Pegcetacoplan is a synthetic cyclic peptide conjugated to a polyethylene glycol polymer that binds specifically to C3 and C3b. Apellis is evaluating pegcetacoplan in several clinical studies across hematology, ophthalmology, nephrology, and neurology. Pegcetacoplan was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) and the treatment of geographic atrophy, and received orphan drug designation for the treatment of C3G by the FDA and European Medicines Agency. For additional information regarding our clinical trials, visit https://apellis.com/our-science/clinical-trials.

About C3 Glomerulopathy (C3G) and Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)
C3G and IC-MPGN are rare, debilitating kidney diseases that affect ~18,000 people in the United States and Europe.¹ There are no approved therapies for the diseases, and symptoms include blood in the urine, dark foamy urine due to the presence of protein, swelling and high blood pressure.² Approximately 50% of people living with C3G and IC-MPGN ultimately suffer kidney failure within five to 10 years of diagnosis.³ Although IC-MPGN is considered a distinct disease from C3G, the underlying cause and progression of the two diseases are remarkably similar and include overactivation of the complement cascade, with excessive accumulation of C3 breakdown products in the kidney causing inflammation and damage to the organ.^4,5