ONCURIOUS I-O Portfolio Directed at Boosting T Cell Influx and Activity in Solid Tumors Announcing First Preclinical Proof of Concept in Proprietary CCR8 Treg Program - Seite 2

Next to the anti-CCR8 program, Oncurious is focusing on 2 other programs aimed at boosting anti-tumor T cell influx and activity in immune excluded tumors. Exclusion of T cells is an immunosuppressive mechanism commonly used by cancers to evade the immune system and as such is an attractive target for new therapeutic modalities.

The company expects to make further announcements regarding its progress in the near future.

Patrik De Haes, M.D., Executive Chairman of ONCURIOUS NV comments, “I am excited about the future of Oncurious based on its portfolio of novel, differentiated I-O therapies. The company’s approach is to generate novel drug candidates to treat immune excluded solid tumors that are not adequately addressed by immune checkpoint inhibitors, which are rapidly becoming the mainstay of cancer therapy. Today we are announcing significant progress in both hit and lead generation against novel I-O targets, including CCR8, which we believe could play a key role in the development of innovative immunotherapies to overcome solid tumor resistance. Working with leading scientists in the field, we aim to be at the forefront of a new wave of the I-O revolution and are confident that by delivering on our goals we can build Oncurious into a company of significant value in the years ahead. We look forward to updating you on our further progress.”

Jérôme Van Biervliet, Managing Director at VIB comments: “We are very pleased to see Oncurious’ anti-CCR8 antibody reach this important step towards preclinical development, not least thanks to the model collaboration with VIB Discovery Sciences.  Side-by-side with the Oncurious team, they are accelerating a promising pipeline of investigational immuno-oncology therapies.”

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For further information please contact:

Oncurious NV Wouter Piepers, Investor Relations & Corporate Communications Tel: [phone] [e-mail]

VIB Elisabeth Stes External Relations Manager [phone] / [phone] [e-mail]

Citigate Dewe Rogerson David Dible/ Sylvie Berrebi/Frazer Hall Tel: [phone] [e-mail]

About ONCURIOUS

Oncurious is a Belgium-based biotech company focused on developing innovative oncology treatments derived from a series of promising new targets that are designed to enhance T cell activity, migration and influx into resistant tumour sites, boosting the patient’s own immune response against cancer.  The company's lead immuno oncology asset is a Treg-depleting asset, targeting a protein specifically expressed on Tregs in the tumour microenvironment. The program is in lead optimization. The company's two other programs are focused on T cell migration and are in the discovery stages.