ERYTECH Announces First Patient Enrolled in a Phase 1 Investigator Sponsored Trial of Eryaspase in First-Line Pancreatic Cancer
ERYTECH Announces First Patient Enrolled in
a Phase 1 Investigator Sponsored Trial of
Eryaspase in First-Line Pancreatic Cancer
- Trial to evaluate safety of eryaspase in combination with FOLFIRINOX for the first-line treatment of pancreatic cancer
- Trial in Progress (TiP) poster accepted for presentation at the American Society of Clinical Onocology – Gastrointestinal Cancers Symposium (ASCO GI)
Lyon (France) and Cambridge, MA (U.S.), January 14th, 2021 – ERYTECH Pharma (Nasdaq & Euronext: ERYP), a clinical-stage biopharmaceutical company developing innovative therapies by encapsulating therapeutic drug substances inside red blood cells, today announced the first patient enrolled in a Phase 1 investigator sponsored trial (IST), named rESPECT, of its lead product eryaspase for the first-line treatment of pancreatic cancer.
The rESPECT Phase 1 IST (NCT04292743) will be conducted by Dr Marcus Noel (Associate Professor of Medicine at Georgetown University, Washington DC, USA). The trial will enroll approximately 18 patients who have received no prior chemotherapy for the treatment of locally advanced or metastatic pancreatic cancer . The dose of eryaspase will be escalated and added to modified FOLFIRINOX to assess the safety and tolerability of the combination. FOLFIRINOX is one of the most commonly utilized first-line chemotherapy regimens for the treatment of pancreatic cancer.
The study has been accepted for poster presentation at the forthcoming Virtual ASCO GI meeting (abstract #TPS453). The TiP poster will be available on ASCO GI’s website starting at 8:00 a.m. ET/1:00 p.m. GMT on Friday 15th January 2021.
Poster is available to view online at the ASCO Virtual meeting website: https://meetinglibrary.asco.org/record/194379/slide
Dr Marcus Noel commented that: “First-line pancreatic cancer remains a challenging disease to treat with few treatment options. Our aim for this study is to demonstrate that eryaspase can be added to existing standard therapy, mFOLFIRINOX. I look forward to sharing the full study rationale and design at the Virtual ASCO GI.”
Dr Iman E-Hariry, Erytech’s Chief Medical Officer, added: “We are delighted to be working alongside Dr Noel at the University of Georgetown. We are grateful to Dr Noel for providing his expertise and leadership in developing and initiating the study protocol. The initiation of this trial represents an important milestone for the program, as we begin to evaluate the potential of eryaspase in first-line pancreatic cancer and anticipate top-line results from the Phase 3 TRYbeCA-1 trial in second-line pancreatic cancer in 2021.”