OSE Immunotherapeutics Receives €1.3 Million Milestone Payment from Bpifrance for OSE-127/S95011 - Seite 2

Ulcerative colitis background
UC is a debilitating inflammatory bowel disease that affects 3.3 million patients in the U.S., Europe and Japan. Despite multiple approved therapeutic options, remission rates are 25-30%², leaving most patients in therapeutic failure and in need of alternative new therapies. The current standard of care is largely comprised of two main therapeutic classes (5-ASAs and TNFα) with a total market size of $6.3 billion³.

¹ Servier is a global independent pharmaceutical group, governed by a non-profit foundation, with headquarters based in France.
² Drugs Context. 2019; 8: 212572 – doi: 10.7573/dic.212572
³ EvaluatePharma

ABOUT THE EFFIMab PROGRAM
This collaborative program is headed by OSE Immunotherapeutics as the leader of the consortium to develop OSE-127/S95011, a monoclonal immunomodulatory antibody targeting the CD127 receptor, the alpha chain of the interleukin-7 receptor (IL-7R). The funding from Bpifrance is planned to cover the product’s development until the Phase 2 clinical stage. The total amount of the OSE-127/S95011 program, being developed by OSE Immunotherapeutics in collaboration with INSERM and Nantes University Hospital, is €20 million with €9.1 million allotted by Bpifrance.

ABOUT OSE Immunotherapeutics
OSE Immunotherapeutics is an integrated biotechnology company focused on developing and partnering therapies to control the immune system for immuno-oncology and autoimmune diseases. The company’s immunology research and development platform is focused on three areas: T-cell-based vaccination, Immuno-Oncology (focus on myeloid targets), Auto-immunity & Inflammation. Its balanced first-in-class clinical and preclinical portfolio has a diversified risk profile:

Vaccine platform

- Tedopi (innovative combination of neoepitopes): the company’s most advanced product; positive results for Step-1 of the Phase 3 trial (Atalante 1) in Non-Small Cell Lung Cancer post checkpoint inhibitor failure.
In Phase 2 in pancreatic cancer (TEDOPaM, sponsor GERCOR) in combination.
- CoVepiT: a prophylactic vaccine against COVID-19, developed using SARS-CoV-2 optimized neo-epitopes. Positive preclinical and human ex vivo results in August 2020, clinical trial expected to start in Q1 2021.

Immuno-oncology platform

- BI 765063 (OSE-172, anti-SIRPα mAb on SIRPα/CD47 pathway): developed in partnership with Boehringer Ingelheim; myeloid checkpoint inhibitor in Phase 1 in advanced solid tumors.