EQS-News

Relief and AdVita Announce Initiation of Phase 2 Trial with Inhaled RLF-100 for the Prevention of COVID-19-related Acute Respiratory Distress Syndrome - Seite 2

Prof. Dr. Joerg D. Leuppi, M.D., Ph.D., lead investigator of the study, commented: "There remains a significant unmet medical need for effective, safe treatments for COVID-19 patients, despite the increase in vaccination rates and the better understanding we now have on how to treat this potentially deadly infection. RLF-100 is a synthetic form of human Vasoactive Intestinal Polypeptide ("VIP"), which is highly concentrated in the lungs and has been shown in clinical studies to reduce inflammation. We believe that RLF-100 has the potential to prevent COVID-19 patients from developing serious lung disease which end in the ICU needing mechanical ventilation and look forward to seeing the results from this phase 2 trial."

Dorian Bevec, Ph.D., CDO of AdVita, commented: "We are delighted that Professor Leuppi and his team are conducting this trial. We are also excited to be working with the Relief team jointly moving forward the development of inhaled RLF-100 in the treatment of moderate to severe COVID-19-induced respiratory deficiency and other potential indications, such as pulmonary sarcoidosis, and look forward to contributing our expertise with this important drug candidate to the development plan."

Gilles Della Corte, M.D., Chief Medical Officer of Relief, said: "This study will be helpful in building the clinical database for inhaled RLF-100 in preventing COVID-19 patients from developing acute respiratory distress syndrome. The results will provide important insight as we advance the development of this product candidate in Europe."

Relief provides update on RLF-100 clinical development in Europe

Relief also today provided an update on development plans for RLF-100 in Europe.

Intravenous (IV) formulation: Relief is currently preparing a European phase 2b/3 study with IV RLF-100 in COVID-19 patients. Once an Emergency Use Authorization ("EUA") application is submitted by partner, NeuroRx, Inc., to the U.S. Food and Drug Administration ("FDA") and a decision is made, Relief will determine the best path forward for the development of IV RLF-100 in Europe and other territories. Relief continues to see the potential value of RLF-100 to help patients with COVID-19-induced lung injury and hopes that, should the FDA grant EUA for RLF-100, this could expedite the clinical assessment of RLF-100 in Europe.