Theradiag Announces the Launch of HUMABDIAG, a Large-scale Research Project Targeting the Bioproduction of Monoclonal Antibodies in Tours

Regulatory News:

THERADIAG (Paris:ALTER) (ISIN: FR0004197747, Ticker: ALTER, eligible for PEA-PME equity savings plans), a company specializing in in vitro diagnostics and theranostics, announces the launch of HUMABDIAG, a large-scale antibody bioproduction research project in Tours.

From July 1, 2021, Theradiag will work with the city of Tours’ academic and industrial ecosystem: its CHRU regional university hospital, its university and deep-tech antibody company MAbSilico, on an antibody research and production project co-financed by the Centre-Val de Loire region to the tune of €450 thousand. This strategic project is an extension of the global collaboration agreement with the university of Tours and the creation of a second site in the Centre-Val de Loire region, announced by the Company in July and September 2020 respectively.

Every patient, when they develop an immune response to a pathogen or antigen, produces a broad range of antibodies; this repertoire of antibodies is specific to that patient. The aim of the HUMABDIAG project is to seek out, in these directories, the most efficient antibodies in their binding with their target, whether that be a viral protein, an immunogenic drug or an autoantigen within the framework of autoimmune diseases.

More specifically, the approach developed in this project allows the rapid identification of antibodies of interest and, more importantly, the identification of their unique genetic sequence. Based on this sequence, it will then be possible to create a computer simulation of the binding between the antibody and its target, and then to reproduce this antibody.

Theradiag will cooperate with the academic players (regional university hospital and university) in putting the concept and technology in place: selection and isolation of lymphocytes of interest and sequencing prior to the computer analysis. MAbSilico will be responsible for the modeling of the antibodies and simulations of their binds to their target using their Artificial Intelligence-based software platform. Theradiag will then transfer the antibodies of interest onto its platform to produce human monoclonal antibodies of diagnostic interest. The resulting human monoclonal antibodies will perfectly reflect the antibodies actually present in patients and their production will be standardized. For Theradiag, this important differentiation will represent major leverage for its strategy and its approach to the In Vitro Diagnostics (IVD) and Theranostics market.