Angle PLC Announces Concordance of Parsortix with tissue biopsy

BREAKTHROUGH STUDY DEMONSTRATES FOR THE FIRST TIME CONCORDANCE OF PARSORTIX LIQUID BIOPSY BLOOD TEST WITH INVASIVE TISSUE BIOPSY OF THE METASTATIC SITE

Study explores key unmet medical need for metastatic breast cancer as over 50% of patients fail to receive successful tissue biopsies of the metastatic site preventing access to essential information to guide their treatment

Potential for Parsortix liquid biopsy blood test as an alternative to invasive surgical tissue biopsy in metastatic breast cancer

GUILDFORD, SURREY / ACCESSWIRE / January 17, 2022 / ANGLE plc (OTCQX:ANPCY)(AIM:AGL), a world-leading liquid biopsy company, is delighted to announce the publication of breakthrough research undertaken by the world-class team at the University of Southern California Norris Cancer Center. The research demonstrates the potential of circulating tumour cells (CTCs) harvested from a simple blood draw using the Company's Parsortix^® system to be used as an alternative to invasive metastatic tissue biopsy for metastatic breast cancer (MBC) patients.

In the United States, guidelines published by the National Comprehensive Cancer Network (NCCN) recommend a tissue biopsy of a secondary cancer site in MBC because of the critical need for up-to-date information on cancer progression to guide treatment decisions. However, over 50% of all MBC patients do not have a successful metastatic tissue biopsy because they are either too ill for the invasive procedure, the cancer site is inaccessible and/or insufficient tissue is available. Hence, there is nothing to guide ongoing treatment decisions in these patients. Even in those patients who can undergo a metastatic tissue biopsy, there is rarely the option for a second such biopsy, yet the cancer continues to evolve, often to multiple sites. A simple, repeatable liquid biopsy alternative using the Parsortix system could resolve the issues with metastatic tissue biopsies and, as the study finds, provide real time information on the cancer evolution to guide treatment options.

The study was the first of its kind to directly compare molecular analysis of matched patient samples from invasive metastatic tissue biopsy with Parsortix-harvested cells from a blood sample. The demonstration of a high concordance between the RNA sequencing (RNA-Seq) results of the two sample types is critical in demonstrating the potential utility of the Parsortix system for use as a routine blood test for cancer patients, which could provide a view on the spread of the disease. It is particularly important as over 90% of patients who die of their cancer die of the metastatic spread of the disease rather than their primary cancer.