C4XD Agreement with AstraZeneca - Seite 2

Inflammation is a key driver in many pathological conditions including respiratory diseases. NRF2 is an important natural regulator, controlling the expression of antioxidant genes, and it plays a key role in cellular defense against external insults, as well as the regulation of the inflammatory response. Targeting the NRF2 pathway to reduce inflammatory damage offers the potential for a new approach to treat a variety of inflammatory diseases such as COPD, where activation of NRF2 may help in reducing the negative effects of the oxidative stress-induced progression of the disease.^3,4. Lead molecules from C4XD's oral NRF2 Activator programme have been found to significantly activate NRF2 following oral dosing, providing anti-inflammatory and antioxidant activity.

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Contacts

C4X Discovery Holdings
Mo Noonan, Communications	[phone]
Panmure Gordon (UK) Limited (NOMAD and Broker)
Freddy Crossley, Emma Earl (Corporate Finance)	[phone]
Rupert Dearden (Corporate Broking)
C4X Discovery Media - Consilium Strategic Communications
Mary-Jane Elliott, Chris Gardner, Matthew Neal	[phone]

Notes to Editors:

About COPD

COPD is the third leading cause of death worldwide, causing 3.23 million deaths in 2019. It is a common, preventable and treatable chronic lung disease which affects men and women worldwide. Abnormalities in the small airways of the lungs lead to a narrowing of the airways, limiting airflow in and out of the lungs and destruction of parts of the lung may be observed.⁵ Cigarette smoking is a major risk factor for COPD, causing a high level of oxidative stress in the lungs and driving chronic inflammation as well as increased severity of infection-induced flare-ups.⁶