Relief Therapeutics to Present Pre-Clinical Evidence for Improved Amino Acid Utilization with PKU GOLIKE at the Society for Inherited Metabolic Disorders 44th Annual Meeting

People living with PKU do not have the ability to metabolize the amino acid phenylalanine (Phe) found in many foods and they require supplementation of amino acid-based foods for special medical purposes (FSMPs) to prevent protein deficiency and optimize metabolic control. These protein substitutes are typically characterized by altered kinetic profiles compared to that of a slowly absorbed and digested intact protein. The rate of amino acid absorption affects the post-prandial utilization of dietary nitrogen, and the prolonged release of amino acids could support anabolic requirements. Developed with Relief Therapeutics' proprietary, patent-protected Physiomimic Technology™ platform, PKU GOLIKE is the first prolonged-release, amino acid FSMP, characterized by a special coating that enables physiological absorption of the amino acids mirroring that of natural proteins.

"The results from this pre-clinical research demonstrate the important body composition benefits of the physiological absorption of our prolonged-release amino acid supplement PKU GOLIKE¹," said Nermeen Varawalla, M.D., Ph.D., chief medical officer at Relief Therapeutics. "The findings provide direction for our forthcoming clinical research to confirm the metabolic benefits of PKU GOLIKE, assessing body composition and oxidative stress in active PKU patients, thereby substantiating our completed pre-clinical work."