NanoViricides Provides an Update on Its Clinical Program and Strategy - NV-387 Could be As Revolutionary as Antibiotics

SHELTON, CT / ACCESSWIRE / August 8, 2024 / NanoViricides, Inc. (NYSE American:NNVC) (the "Company"), a clinical stage global leader in broad-spectrum antiviral nanomedicines, is providing an update on its clinical program and strategy in this letter to investors.

NanoViricides is developing a unique direct-acting antiviral drug that mimics the host cell and thereby is designed to disable the virus particle from infecting the cell. Our first clinical stage drug, NV-387 is designed to mimic the ubiquitous sulfated-proteoglycan ("S-PG") features that over 90% of pathogenic human viruses utilize to infect human cells. Thus, NV-387 is expected to be a revolutionary antiviral drug with an ultra-broad-spectrum antiviral potential, akin to penicillin when it was first developed as a broad-spectrum antibiotic.

The Company has already found that NV-387 was superior to or equivalent to existing drugs in non-clinical animal trials in the case of three major classes of viruses: Influenza, COVID, and RSV; the so-called "triple-demic" respiratory viruses - and even orthopoxviruses (Smallpox/Mpox).

In fact, NV-387 was found to cause complete survival of lethally lung infected mice in an RSV efficacy study, with full protection of lungs, indicating potential cure. There is no currently approved drug for treating RSV infection once it takes place (Ribavirin, a toxic drug approved for RSV as a last resort only, did not lead to protection of the animals).

Such a broad-spectrum of antiviral effectiveness as demonstrated in animal models implies that it is highly unlikely that any given virus can create mutants or variants that are substantially or completely resistant to NV-387. Thus NV-387, unlike the much touted conventional medical countermeasures (MCMs) approaches of vaccines, antibodies, and small molecule antivirals, promises to solve the greatest problem in antiviral therapeutics. The viruses readily escape current MCMs, but are highly unlikely to escape NV-387.

Together, just the three viruses, Influenza, RSV, and COVID, account for over $8 Billion in estimated market size in 2024, growing to an estimated $12 Billion in three years, as calculated by us from various market reports.

But the list of S-PG-using viruses is far bigger than these three viruses. It includes Dengue viruses, Zika virus, Yellow Fever virus, West Nile virus, Hendra and Nipah viruses, Echoviruses, CoxSackie virus, Noroviruses, Rabiesvirus, Rhinoviruses, Ebola/Marburg viruses, Foot-and-Mouth-Disease virus (FMDV), Chickengunya virus, and many others that have been causing headlines throughout the world.