Alpha Cognition Receives Notice of Allowance for Composition-of-Matter Patent for ZUNVEYL for Mild to Moderate Alzheimer’s Disease

Alpha Cognition Inc. (CSE: ACOG) (OTCQB: ACOGF) (Alpha Cognition “ACI”, or the “Company”), a biopharmaceutical company developing novel therapeutics for debilitating neurodegenerative disorders, is pleased to announced the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for patent application No. 18/463,157, entitled “Solid Forms of ALPHA-1062 Gluconate,” which includes claims covering an additional novel crystalline solid form of ZUNVEYL and complements existing patents that the Company holds for ZUNVEYL. The patent provides protection for a second commercially viable form of the drug. A Notice of Allowance is issued after the USPTO makes the determination that the claimed invention is patentable, and a patent should be granted from an application.

This Notice of Allowance is a critical milestone in our mission to develop transformative therapies for Alzheimer’s disease. It not only recognizes the innovative nature of our research but also strengthens the Company’s ability to protect the long patent life through 2042 that ZUNVEYL has in the United States market.

"Allowance of this composition-of-matter patent, covering a specific solid form of benzgalantamine, provides another important layer of proprietary intellectual property protection for our lead asset, ZUNVEYL, an FDA-approved medication for the treatment of mild to moderate Alzheimer’s disease," said Michael McFadden, Chief Executive Officer of Alpha Cognition. "Claims covering additional forms of ZUNVEYL build on the patent protection the Company holds for this product."

About Alpha Cognition Inc.

Alpha Cognition Inc. is a commercial stage, biopharmaceutical company dedicated to developing treatments for patients suffering from neurodegenerative diseases, such as Alzheimer’s disease and Cognitive Impairment with mild Traumatic Brain Injury (“mTBI”), for which there are currently no approved treatment options.

ZUNVEYL is a patented drug approved as a new generation acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease, with expected minimal gastrointestinal side effects. ZUNVEYL’s active metabolite is differentiated from donepezil and rivastigmine in that it binds neuronal nicotinic receptors, most notably the alpha-7 subtype, which is known to have a positive effect on cognition. ALPHA-1062 is also being developed in combination with memantine to treat moderate to severe Alzheimer’s dementia, and as an intranasal formulation for Cognitive Impairment with mTBI.