Incyte Announces Multiple Presentations, Including New Late-Breaking Data for its mutCALR-Directed Monoclonal Antibody (INCA033989), Accepted for Presentation at EHA 2025

Incyte (Nasdaq:INCY) today announced that data from numerous programs in its hematology/oncology portfolio will be presented at the 2025 European Hematology Association (EHA) congress, held June 12 – 15, 2025, in Milan.

"We're looking forward to presenting new data from across our hematology/oncology portfolio at the 2025 EHA Congress, including late-breaking data for our first in class, mutCALR-directed monoclonal antibody, INCA033989,” said Pablo J. Cagnoni, M.D., President and Head of Research and Development, Incyte. “We believe the data that will be presented at the late-breaking session demonstrate the impact of the novel mechanism of action of this monoclonal antibody against mutCALR-driven essential thrombocythemia (ET), and support its potential to be a disease modifying agent and thus transform the treatment of patients with myeloproliferative neoplasms (MPNs) like essential thrombocythemia (ET)."

Key Incyte abstracts accepted for presentation at EHA include:

Late-Breaking Oral Presentation

INCA033989 (mutCALR)

INCA33989 is a Novel, First in Class, Mutant Calreticulin-Specific Monoclonal Antibody That Demonstrates Safety and Efficacy in Patients with Essential Thrombocythemia (ET)
(Session Title: Late-Breaking Oral Session. June 15, 3:15 – 4:45 a.m. EDT [9:15-10:45 a.m. CEST]. Abstract #LB4002.)

Oral Presentations

INCA035784 (mutCALR)

INCA035784, a Novel, Equipotent T Cell Redirecting Antibody for Patients with Myeloproliferative Neoplasms Carrying Different Types of Calreticulin Mutations
(Session Title: Novel and Experimental Approaches to Study and Treat MPN. June 15, 5:30 – 5:45 a.m. EDT [11:30 – 11:45 a.m. CEST]. Abstract #S212.)

Ruxolitinib

Clinical Outcomes in Patients with Myelofibrosis Treated with Ruxolitinib and Anemia Supporting Medications
(Session Title: Assessment of Risk and Survival in MPN. June 13, 11:45 a.m. – 12:00 p.m. EDT [5:45 – 6:00 p.m. CEST]. Abstract #S218.)

Tafasitamab

Tafasitamab (tafa) Plus Lenalidomide (len) and Rituximab (R) for Patients with Relapsed or Refractory Follicular Lymphoma (R/R FL): Results from the Phase 3 inMIND Study
(Session: Indolent and Mantle-Cell Non-Hodgkin Lymphoma - Clinical. June 14, 11:00 – 11:15 a.m. EDT [5:00 – 5:15 p.m. CEST]. Abstract #S230.)

Poster Presentations

Axatilimab

Trial in Progress: A Randomized, Open-Label, Phase 3 Study of Axatilimab Versus Best Available Therapy in Patients with Chronic Graft-Versus-Host Disease After ≥2 Prior Lines of Systemic Therapy