Junshi Biosciences Announces the Phase 3 Study of JS005 (IL-17A) for the Treatment of Moderate to Severe Plaque Psoriasis Met Primary Endpoints - Seite 2

The study results showed that, compared to the placebo, JS005 significantly improved the area and severity of psoriasis lesion in participants, and the proportion of participants achieving a sPGA score of 0 or 1 was also significantly higher, and JS005 demonstrated good safety in participants with moderate to severe plaque psoriasis. The relevant study results will be announced at future international academic conferences.

Prof. Jianzhong ZHANG from the Peking University People’s Hospital said, “Patients with moderate-to-severe psoriasis suffer from long-term recurrent skin lesions and pruritus, imposing significant physical and mental burdens. Traditional treatments remain limited, making the success of this Phase 3 study for JS005 a significant milestone. Results demonstrate JS005’s superior efficacy in achieving deep symptom remission, sustained therapeutic effects, and improved quality of life. We hope this therapy will soon benefit millions of patients, further advancing China’s psoriasis treatment landscape.”

Dr. Jianjun ZOU, General Manager and CEO of Junshi Biosciences, said, “We sincerely thank patients, investigators, and the R&D team for their exceptional contributions in achieving the primary endpoints of JS005’s Phase 3 study. This milestone not only brings new hope to patients with moderate-to-severe psoriasis but also marks our innovation breakthrough in the autoimmune field. Moving forward, we will actively collaborate with regulators to accelerate the availability of this innovative therapy, ensuring earlier patient access.”

About JS005

JS005 is an anti-IL-17A monoclonal antibody independently developed by Junshi Biosciences. IL (interleukin)-17A is a pleiotropic cytokine, and the disordered secretion of which is closely related to the occurrence and progression of autoimmune diseases such as psoriasis, rheumatoid arthritis and ankylosing spondylitis. By binding to IL-17A with high affinity and selectively blocking the binding of IL-17A with its receptor IL-17RA/IL-17RC, JS005 blocks the activation of downstream signaling pathways and the release of inflammatory factors, thereby effectively alleviating the symptoms of autoimmune diseases. So far, the phase 3 clinical study of JS005 for the treatment of moderate to severe plaque psoriasis has met the co-primary endpoints and key secondary endpoints. All subjects in the phase 2 clinical study of JS005 for the treatment of active ankylosing spondylitis have completed the primary endpoint visit and entered the extension treatment period.