Emergent BioSolutions Receives New Contract Modification for ACAM2000, (Smallpox and Mpox (Vaccinia) Vaccine, Live) from the U.S. Government, Further Demonstrating Importance of Public Health Preparedness

GAITHERSBURG, Md., Sept. 09, 2025 (GLOBE NEWSWIRE) -- Emergent BioSolutions Inc. (NYSE: EBS) today announced that a contract modification has been executed in the amount of $56 million to supply ACAM2000, (Smallpox and Mpox (Vaccinia) Vaccine, Live) to the U.S. government. Deliveries are expected to begin this month. This brings the total projected sales for ACAM2000 vaccine and ancillary products to more than $120 million this year from a diverse base of customers. ACAM2000 is licensed for active immunization against smallpox and mpox disease for persons determined to be at high risk for smallpox or mpox infection.

“Our new contract modification for ACAM2000 vaccine reflects the continued collaboration between Emergent and the U.S. government to prioritize preparedness support,” said Paul Williams, senior vice president, head of products business, global government & public affairs at Emergent. “With our North American manufacturing and supply chain capabilities at the ready, and Emergent’s commitment to being a trusted partner of the U.S. government and offering most favored pricing as part of that commitment, we are helping to strengthen public health efforts through our medical countermeasures portfolio.”

ACAM2000 is a single-dose vaccine administered percutaneously via a bifurcated needle that is dipped into the vaccine solution that is used to prick the skin several times in the upper arm with a droplet of the vaccine. The vaccine was first approved by the U.S. Food and Drug Administration (FDA) in 2007 for active immunization for the prevention of smallpox disease in individuals determined to be at high risk for smallpox infection, and was FDA approved in August 2024 for immunization against mpox in individuals determined to be at high-risk for mpox. ACAM2000 is also licensed for smallpox in Canada, Australia and Singapore and is currently stockpiled both in the U.S. and internationally.

This contract modification is under Emergent’s existing 10-year contract (75A50119C00071) with the Administration for Strategic Preparedness and Response (ASPR) at the United States Department of Health and Human Services.

About ACAM2000, (Smallpox and Mpox (Vaccinia) Vaccine, Live)

Indication

ACAM2000 is indicated for active immunization for the prevention of smallpox and mpox disease in individuals determined to be at high risk for smallpox and mpox infection.

Select Important Safety Information

Boxed Warning: Serious Complications
Myocarditis and pericarditis (suspect cases observed at a rate of 5.7 per 1000 primary vaccinees (95% CI: 1.9-13.3)), encephalitis, encephalomyelitis, encephalopathy, progressive vaccinia, generalized vaccinia, severe vaccinial skin infections, erythema multiforme major (including STEVENS-JOHNSON SYNDROME), eczema vaccinatum resulting in permanent sequelae or death, accidental eye infection (ocular vaccinia) which can cause ocular complications that may lead to blindness, and fetal death, have occurred following either primary vaccination or revaccination with ACAM2000 or other live vaccinia virus vaccines that were used historically. These risks are increased in certain individuals and may result in severe disability, permanent neurological sequelae and/or death.