Jade Biosciences Announces JADE201, a Potentially Best-in-Class Half-Life Extended Afucosylated Anti-BAFF Receptor Monoclonal Antibody in Development for Autoimmune Diseases

• JADE201 builds on clinical proof-of-concept for BAFF-R targeting, adding half-life extension technology to provide extended receptor occupancy with the goal of delivering deeper, more durable B cell depletion with less frequent subcutaneous dosing 
  
• JADE201’s high affinity binding and extended half-life enabled dose-dependent BAFF receptor occupancy and sustained B cell depletion in non-human primates
  
• First-in-human trial in rheumatoid arthritis expected to begin in the first half of 2026; potential for broad opportunity across multiple autoimmune diseases validated by BAFF-R biology
  
• Company to host conference call and webcast today at 8:00 a.m. ET
  

SAN FRANCISCO and VANCOUVER, British Columbia, Oct. 07, 2025 (GLOBE NEWSWIRE) -- Jade Biosciences, Inc. (the ”Company” or “Jade”) (Nasdaq: JBIO), a clinical-stage biotechnology company focused on developing best-in-class therapies for autoimmune diseases, today unveiled JADE201, its investigational half-life extended, afucosylated monoclonal antibody targeting the B-cell activating factor receptor (BAFF-R). JADE201 is designed to overcome the limitations of current B cell-directed therapies by combining a dual mechanism of action and half-life extension technology, with the goal of improving on the clinical benefit of existing B-cell depleting therapies across a broad range of autoimmune diseases.

“JADE201 reflects the progress we are making to build a complementary portfolio of therapies that modulate B-cell biology,” said Tom Frohlich, Chief Executive Officer of Jade. “JADE201 bolsters our portfolio of autoimmune disease therapies, which includes JADE101, a potentially best-in-class anti-APRIL monoclonal antibody being studied for the treatment of IgA nephropathy. JADE201 combines a validated mechanism of action with half-life extension designed to enable potent activity with more patient-friendly, infrequent dosing as we work to advance new standards of care for autoimmune diseases. Jade has a world-class team of drug developers, which combined with our strengthened balance sheet following our recent private financing, positions us well to execute on our mission.”