IGC Pharma Expands Phase 2 CALMA Clinical Trial to University of South Florida's Department of Psychiatry and Behavioral Neurosciences

POTOMAC, MD / ACCESS Newswire / October 14, 2025 / IGC Pharma, Inc. ("IGC Pharma," "IGC," or the "Company") (NYSE American:IGC), a clinical-stage biotechnology company leveraging AI to develop innovative treatments for Alzheimer's disease, today announced the expansion of its ongoing Phase 2 CALMA clinical trial evaluating investigational drug candidate IGC-AD1 for agitation in Alzheimer's disease. The trial has officially opened a new site at the University of South Florida's Department of Psychiatry and Behavioral Neurosciences, under the leadership of Principal Investigator Dr. Ram Bishnoi.

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Enrollment at the new site has already begun, with four participants enrolled, marking an important step toward accelerating recruitment and advancing the timeline of the study. The addition of USF, a leading research and academic institution, underscores IGC Pharma's commitment to partnering with distinguished investigators to address the urgent, unmet needs of patients living with Alzheimer's disease.

"The opening of this site at the University of South Florida strengthens our ability to recruit diverse participants while ensuring the highest standard of clinical oversight," said Ram Mukunda, CEO of IGC Pharma. "USF brings a strong academic pedigree, deep expertise in behavioral neuroscience, and an established record in clinical research. With enrollment already underway, we're pleased to see continued momentum in advancing the CALMA trial."

The CALMA Phase 2 trial is a randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of IGC-AD1 in reducing agitation in patients with Alzheimer's disease. With the addition of USF, CALMA continues to expand across multiple clinical sites in North America.

About the University of South Florida Department of Psychiatry and Behavioral Neurosciences

The Department of Psychiatry and Behavioral Neurosciences at the University of South Florida Morsani College of Medicine is a leading academic and clinical institution dedicated to improving mental health through an integrated mission of clinical care, education, and research. Founded in 1971 as USF's first residency training program, the department has achieved national and international recognition for its innovative approaches to treating mental, addictive, and behavioral disorders.