NANOBIOTIX Announces Curadigm Nanoprimer Platform Advancements With Updated Plans for Internal Pipeline Development and External Collaborations

• Four new patent applications filed that aim to expand the Curadigm Nanoprimer platform intellectual property portfolio and support an initial proprietary internal pipeline of Nanoprimer products in addition to external collaborations
• New in vivo pre-clinical data evaluating the Nanoprimer in combination with therapeutic vaccines were presented at the 2025 Partnership Opportunities in Drug Delivery conference (PODD) that will serve as the foundation for an initial internal proprietary pipeline of Nanoprimer products
• Momentum building for external collaborations featuring Nanoprimer platform combinations with numerous material transfer agreements already in place
• Chemistry, Manufacturing, and Controls (CMC) activities launched to support both internal pipeline and external collaborations

PARIS and CAMBRIDGE, Mass., Nov. 13, 2025 (GLOBE NEWSWIRE) -- NANOBIOTIX (Euronext: NANO –– NASDAQ: NBTX – the ‘‘Company’’), a late-stage clinical biotechnology company pioneering physics-based approaches to expand treatment possibilities for patients with cancer and other major diseases, today announced advancements for its next-wave Curadigm Nanoprimer platform.

The Curadigm Nanoprimer is designed to address one of the most universal challenges in modern medicine—the effective extrahepatic delivery of innovative therapeutic agents that are administered intravenously (“IV”) such as RNA-based vaccines, peptide-based vaccines, and oncolytics viruses. Built from precisely engineered lipid-based nanoparticles, the Nanoprimer is intended to transiently occupy liver pathways responsible for therapeutic clearance. By doing so, the Nanoprimer enables a greater fraction of subsequently administered therapeutic agents to reach their intended target tissues, potentially improving efficacy or reducing liver-related toxicity.

Nanobiotix expects the Curadigm Nanoprimer platform to function as a significant driver of long-term growth for the Company, with plans for proprietary internal development of a suite of Nanoprimer products and building momentum for the Nanoprimer platform as a hub for external collaboration.

Four New Patent Applications Filed to Expand Intellectual Property Foundation and Fuel Business Development Activity

Building on a strong intellectual property foundation, Nanobiotix has filed four new patent applications to cover the Curadigm platform and several potential product applications. Taken together with the intellectual property protections already in place, these filings aim to support the further exploration of the Curadigm platform as a hub for external collaboration as well as the creation of an initial proprietary pipeline.