Biogen Completes Acquisition of Alcyone Therapeutics

CAMBRIDGE, Mass., Nov. 14, 2025 (GLOBE NEWSWIRE) -- Biogen Inc. (Nasdaq: BIIB) has completed the acquisition of Alcyone Therapeutics, a clinical-stage biotechnology company known for its innovative CNS therapy delivery solutions, such as the ThecaFlex DRx drug delivery system.

ThecaFlex DRx is an investigational implantable device designed to provide an alternative to repeat lumbar punctures in chronic intrathecal administration of medicines, which could ease both patient experience and accessibility for a broader population of people living with neurologic disorders.

ThecaFlex DRx has been in development since 2019, with the PIERRE and PIERRE-PK clinical studies for nusinersen currently underway. Nusinersen is currently marketed under the brand name SPINRAZA and is indicated for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients. Biogen plans to introduce the new drug delivery system for SPINRAZA in early 2028, contingent upon the successful completion of clinical trials and regulatory approval.

“The ThecaFlex DRx allows us to merge Biogen’s cutting-edge biopharmaceutical innovation with advanced medical device technology to strengthen Biogen’s portfolio and expand our expertise in pioneering new delivery methods,” said Lisa Shafer, Head of CMC Development, Product Delivery Solutions at Biogen. “This acquisition affirms our continued commitment to drug delivery solutions with the potential to enhance the patient experience and enable greater accessibility to Biogen’s therapies.”

About The ThecaFlex DRx System
The ThecaFlex DRx System (ThecaFlex), a technology within Alcyone’s Falcon Delivery Platform, is an investigational implantable intrathecal (IT) catheter, catheter fixation device and subcutaneous port system designed to provide access to the cerebrospinal fluid (CSF) for the infusion of therapies by IT bolus administration. Lumbar puncture (LP) is the current standard of care approach to delivering therapeutics into the CSF. ThecaFlex is designed to be an alternative to repeated LP. ThecaFlex has received a CE Mark in Europe and IDE (Investigational Device Exemption) from the U.S. Food and Drug Administration (FDA) to conduct a clinical investigation but has not yet been approved for commercial use by FDA. In addition, ThecaFlex has received Breakthrough Device Designation from FDA.