Nexalin Announces Peer-Reviewed Study Showing the Company’s DIFS Technology Reduced Self-Injury and Depression Symptoms in Female Adolescents

BMC Psychiatry publication reports statistically significant reductions in self-injury behaviors and depressive symptoms, with brain-network findings further supporting Nexalin’s differentiated, non-invasive DIFS approach

Publication adds to Nexalin’s growing body of peer-reviewed evidence across insomnia and depression, TBI and PTSD, Alzheimer’s disease and ADHD

Houston, TX, April 09, 2026 (GLOBE NEWSWIRE) -- Nexalin Technology, Inc. (Nasdaq: NXL) (the “Company” or “Nexalin”), the leader in Deep Intracranial Frequency Stimulation (DIFS) of the brain, today announced another publication of a peer-reviewed study in BMC Psychiatry reporting that Nexalin’s DIFS 77.5 Hz high-gamma approach was associated with statistically significant reductions in self-injury behaviors and depressive symptoms in female adolescents with non-suicidal self-injury (NSSI). The study also reported measurable changes in brain-network activity and connectivity, providing additional neurophysiological evidence supporting Nexalin’s non-invasive, high-power DIFS technology.

The article, titled, “High-gamma tACS may regulate brain network connectivity to alleviate symptoms in female adolescent non-suicidal self-injury: a preliminary TMS-EEG pilot study,” evaluated six female adolescent patients who received 21 days of 77.5 Hz, 15 mA stimulation using a Nexalin Technology, Inc. device. According to the publication, patients showed statistically significant improvements in depressive symptoms and self-injury behaviors, with benefits persisting through follow-up assessments. The paper further found changes in functional connectivity across emotional-control networks, including Default, Limbic, Salience/Ventral Attention, and Control networks.

Nexalin continues to publish scientific data with neuroimaging and biomarker evidence establishing clinical relevance of its high-power 15 mAmp waveform that supports its DIFS technology. Nexalin’s continued establishment of scientific biomarkers challenges the status quo of all current neurostimulators and the Company believes it positions Nexalin technology to become the world’s leader in non-invasive neurostimulation of the whole brain for the treatment of mental health disorders.

Key findings reported in the publication include:

• Significant improvement in HAMD-24 depression scores after treatment and through follow-up
• Significant reduction in OSIC self-injury scores, including decreases in self-injury thoughts and behaviors
• Improvement in anxiety and sleep quality measures
• All patients met the paper’s predefined clinical response criterion for depression, and 5 of 6 patients (83.3%) met the response criterion for self-injury outcomes
• No significant adverse effects were observed, with only one mild headache reported that resolved quickly

The authors concluded that 77.5 Hz stimulation may alleviate NSSI symptoms in female adolescents by regulating brain activity and functional connectivity in emotional control networks and described the findings as preliminary evidence supporting further investigation in larger randomized controlled trials. The study was accepted on March 10, 2026, and published as an Article in Press in BMC Psychiatry.

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