Exagen Announces Publication of Systematic Review Confirming Robust Real-World Performance of AVISE Lupus

Uniquely identified ~25% of the SLE patients who would otherwise be missed by conventional markers

Demonstrated superior diagnostic accuracy compared with conventional testing, supporting earlier, more definitive diagnosis

Performed consistently across more than 1,200 SLE patients and 14 medical centers, expanding on the original clinical validation

CARLSBAD, Calif., June 01, 2026 (GLOBE NEWSWIRE) -- Exagen Inc. (Nasdaq: XGN), a leading provider of autoimmune testing solutions, today announced the publication of a new systematic review demonstrating that the AVISE Lupus algorithm delivers markedly superior diagnostic accuracy and consistency across patient populations compared with conventional serologic tests alone. AVISE Lupus’ enhanced sensitivity and specificity address key diagnostic gaps, supporting an earlier, more definitive Systemic Lupus Erythematosus (SLE) diagnosis, with the potential for earlier intervention, prevention of organ damage and improved long-term outcomes.

“This publication reinforces Exagen’s powerful and durable competitive moat – AVISE Lupus routinely demonstrates leading SLE diagnostic performance,” said John Aballi, President and CEO. “Built on more than a decade of evidence and over 1,200 SLE patients across leading academic medical centers, the study represents one of the most extensive evidence-generation efforts behind any lupus diagnostic and sets a new standard for rigor in the category. With more than 1 million patients tested since AVISE Lupus launched in 2012, this publication further strengthens our real-world evidence base, supporting our premium market position, reimbursement strategy and broader adoption. Exagen has built a platform that consistently outperforms the standard of care, positioning us to expand our leadership in autoimmune diagnostics.”

The paper, titled “Clinical Utility of a Multianalyte Lupus Risk Score Incorporating Cell-Bound Complement Activation Products: A Systematic Evaluation,” was published in Lupus Science & Medicine. The analysis consolidated biomarker data for 3,132 individuals from 14 academic medical centers in studies conducted between 2011 and 2025 and found that AVISE Lupus performed strongly across patient populations and uniquely identified 25% of patients otherwise missed by conventional serologies, including anti-dsDNA, anti-Smith, and complements C3 and C4.

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