NeuroOne(R) Highlights Potential Paradigm Shift for Patients Treated With the OneRF(R) Brain Ablation System Based on Reports by Physicians

EQS-News: NeuroOne Medical Technologies / Key word(s): Financial NeuroOne(R) Highlights Potential Paradigm Shift for Patients Treated With the OneRF(R) Brain Ablation System Based on Reports by Physicians 28.07.2026 / 14:33 CET/CEST The issuer is solely responsible for the content of this announcement. Large, Single-Center Patient Cohort Demonstrates Meaningful Reductions in Seizure Frequency and Severity, While Improving Patient Quality of Life*

Growing Real-World Evidence Demonstrates an Emerging Diagnosis-to-Therapy Paradigm through the OneRF Brain Ablation System

EDEN PRAIRIE, MINN. - July 28, 2026 (NEWMEDIAWIRE) - NeuroOne Medical Technologies Corporation (Nasdaq: NMTC) (“NeuroOne” or the “Company”), a medical technology company dedicated to transforming the surgical diagnosis and treatment of neurological disorders, today announced physician experience from a large cohort of epilepsy patients treated with the OneRF Ablation System at the Mayo Clinic in Jacksonville, Florida.

The team, led by neurologist Dr. Brin Freund and the late neurosurgeon Dr. Sanjeet Grewal, performed RF ablations on 25 patients with drug-resistant focal epilepsy. Following diagnostic stereo-EEG (SEEG) monitoring with NeuroOne electrodes, the physicians evaluated each patient's seizure foci to determine whether RF ablation could be performed safely. All patients were considered appropriate candidates for RF ablation based on their anatomy and seizure localization. The physicians evaluated safety, seizure outcomes, and patient-reported quality of life.

The physicians reported that among the 25 evaluable patients, the procedure was well tolerated, with rare short-term effects and no serious long-term complications observed. The majority of patients experienced meaningful reductions in seizure frequency, while some achieved sustained seizure freedom either directly following the RF ablation, or after subsequent surgical or medical therapy guided by data from the RF ablation. Most patients also reported improved quality of life and satisfaction with the procedure. Ablation targets ranged from small, discrete seizure areas to multifocal or more extensively distributed epileptic networks.

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