Medigene AG

Medigene presents posters on immunotherapies at CRI-CIMT-EATI-AACR Conference

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Planegg (pta005/16.08.2017/07:30) - - First poster reports of a semi-automated method for the isolation and initial characterization of neoantigen-specific T cell receptors (TCRs)
- Second poster describes Medigene's PRAME-specific TCR for adoptive T cell immunotherapy of cancer

Medigene AG (FSE: MDG1, Prime Standard, TecDAX) today announced that scientists of the Company were invited to present two posters on its T cell receptor (TCR)-modified T cell therapies during the upcoming CRI-CIMT-EATI-AACR Conference. The Cancer Research Institute (CRI), the Association for Cancer lmmunotherapy (CIMT), the European Academy of Tumor Immunology (EATI), and the American Association for Cancer Research (AACR) sponsor the Third International Cancer lmmunotherapy Conference that takes place in Mainz, Germany, from September 6-9, 2017.

During the "Neoantigens and Cancer Mutations" session, Dr. Christiane Mummert, scientist at Medigene Immunotherapies, will present her poster describing a semi-automated method for the isolation and initial characterization of neoantigen-specific T cell receptors. In summary, the experiments demonstrated that neoantigen-specific TCRs can be isolated from peripheral blood samples of healthy donors and initially characterized in eight to ten weeks using an innovative high-throughput robotics platform.

On the second poster, presented during the "Adoptive Cell Therapy" session, shared co-authors Dr. Christian Ellinger and Dr. Manon Weis describe properties of Medigene's PRAME-specific TCR for adoptive T cell immunotherapy of cancer. Using an innovative TCR isolation and characterization platform, a TCR with natural high avidity for a PRAME-derived epitope was isolated showing potent efficacy and a favorable safety profile that will be further evaluated in clinical trials.

Both posters will be presented during "Poster Session A" that will take place on September 6 between 6:00 pm - 8:00 pm.

About Medigene's TCR technology: The TCR technology aims at arming the patient's own T cells with tumor-specific T cell receptors (TCRs). The receptor-modified T cells are then able to detect and efficiently kill tumor cells. This immunotherapy approach attempts to overcome the patient's tolerance towards cancer cells and tumor-induced immunosuppression by activating and modifying the patient's T cells outside the body (ex vivo).