ProMIS Neurosciences Lead Product Candidate, PMN310, Shows Desired Target Binding Profile in Direct Comparison to Other Amyloid Beta-Directed Antibodies for Alzheimer's Disease

Narrated presentation of results available on ProMIS website

TORONTO and CAMBRIDGE, Mass., Oct. 17, 2017 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc., a biotechnology company focused on the discovery and development of precision treatments for neurodegenerative diseases, today announced that its lead product candidate for Alzheimer's disease, PMN310, showed the desired binding profile of selectively targeting amyloid beta oligomers in a preclinical study directly comparing PMN310 to other amyloid beta-directed antibodies for Alzheimer's disease (AD).

A narrated presentation of these results is available on the ProMIS Neurosciences website at: http://bit.ly/2gp8S4t

Commenting on these results, ProMIS President and CEO, Elliot Goldstein, MD, stated: "We are pleased to confirm the selective binding of PMN310 to amyloid beta oligomers, a root cause of Alzheimer's disease. Results of prior clinical studies with other amyloid beta antibody therapeutics clearly showed that antibodies targeting amyloid beta monomer have consistently been ineffective, while those targeting amyloid beta fibrils, the main component of plaque, are associated with a dose limiting toxicity of brain swelling. Taken together, results of prior clinical trials indicate the best in class target product profile is selective binding of toxic amyloid beta oligomers."

The binding profile of PMN310 was compared to that of other candidate antibody therapeutics for AD in a preclinical study using the "dot blot" technique. Results of the study showed that PMN310 selectively binds amyloid beta oligomers (AbetaO), with virtually no binding to the other forms of amyloid beta. By comparison, solanezumab (Eli Lilly) showed binding mainly to Abeta monomers; bapineuzumab (Johnson & Johnson/Pfizer, discontinued) showed binding to all forms of Abeta (monomers, fibrils, oligomers); and aducanumab (Biogen) showed preferential binding to fibrils and oligomers.

Dot blotting is a method of applying (dotting) proteins, such as Abeta monomers, fibrils and oligomers, directly onto a membrane or other support. Samples of the antibody to be evaluated are then applied and the binding pattern to the various forms of amyloid beta can be observed.

About ProMIS Neurosciences, Inc.

ProMIS Neurosciences is a Toronto Stock Exchange listed biotech company (trading symbol: PMN.TO), headquartered in Toronto, Ontario with offices in Cambridge, Massachusetts. The Company's mission is to discover and develop precision medicine therapeutics for effective treatment of neurodegenerative diseases, in particular Alzheimer's disease and ALS.