Bavarian Nordic Announces First Half 2023 Results - Seite 2

Highlights from the period

• In May, Bavarian Nordic completed its acquisition of the travel vaccine portfolio from Emergent BioSolutions, thereby assuming ownership of two marketed vaccines – Vivotif for the prevention of typhoid fever and Vaxchora for the prevention of cholera as well as CHIKV VLP, a Phase 3 vaccine candidate for the prevention of chikungunya virus. The acquisition further included a Swiss-based manufacturing facility and US-based research and development facilities and personnel. Upon closing, Bavarian Nordic made a cash payment to Emergent BioSolutions of USD 274 million, which included estimated adjustments for net working capital, debt and other customary closing adjustments.
• In June, Bavarian Nordic reported Phase 3 topline results of its COVID-19 booster vaccine candidate, ABNCoV2. While the study met its primary objective, demonstrating non-inferiority to an approved mRNA-vaccine in terms of neutralizing antibodies against the original SARS-CoV-2 virus (Wuhan wild type), this may be insufficient to support licensure as the ability of the vaccine to provide efficacy at more distant circulating variants will also be important in the assessment by the authorities of the overall efficacy of ABNCoV2. Also, long-term follow-up results from a Phase 2 trial of ABNCoV2 were reported, showing persistent antibody levels associated with protection against the SARS-CoV2 index virus (Wuhan) 12 months post the booster vaccination with ABNCoV2, while lower levels were seen against a circulating Omicron variant (XBB.1.1), associated with a reduced level of efficacy.
• In June, Bavarian Nordic reported initial results from the first Phase 3 trial of CHIKV VLP, showing that CHIKV VLP was immunogenic in healthy adults ≥65 years of age, as demonstrated by a strong induction of CHIKV neutralizing antibodies against chikungunya in 87% of vaccinees 22 days after vaccination, thus meeting the primary endpoint of the study.
• In June, Bavarian Nordic announced a contract award of EUR 10 million to supply smallpox vaccines to rescEU, a strategic reserve within the European Union (EU) which aims to strengthen the EU’s ability to respond to biological threats in the future.

Events after the reporting date