Black Diamond Therapeutics to Present Preclinical and Clinical Data at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

CAMBRIDGE, Mass. and NEW YORK, Oct. 04, 2023 (GLOBE NEWSWIRE) -- Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a clinical-stage precision oncology company developing therapies that target families of oncogenic mutations in patients with genetically defined cancers, today announced forthcoming presentations during the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston, October 11-15, 2023. The three poster presentations include initial dose escalation data from the Company’s Phase 1 clinical trial of BDTX-1535 in non-small cell lung cancer (NSCLC), the study design of this ongoing Phase 1 clinical trial, and preclinical data for BDTX-4933.

Details for the presentations are as follows:

Title: Phase 1 Study of BDTX-1535, an Oral 4^th Generation EGFR Inhibitor, in Patients with NSCLC and
GBM: Preliminary Dose Escalation Results
Speaker: Helena Yu, M.D., Associate Attending Physician, Memorial Sloan Kettering Cancer Center
Time: Poster Session C, Saturday, October 14, 12:30 pm-4:00 pm
Location/Poster #: Level 2, Exhibit Hall D, #C022

Title: A Phase 1 Study to Assess BDTX-1535, an Oral 4^th Generation EGFR Inhibitor, in Patients with NSCLC and GBM
Speaker: Helena Yu, M.D., Associate Attending Physician, Memorial Sloan Kettering Cancer Center
Time: Poster Session C, Saturday, October 14, 12:30 pm-4:00 pm
Location/Poster #: Level 2, Exhibit Hall D, #C036

Title: Preclinical Efficacy of BDTX-4933, a Brain-penetrant, Orthosteric RAF Inhibitor, Targeting Oncogenic RAF Conformation Shared by Groups of BRAF and Upstream Driver Mutations
Speaker: Elizabeth Buck, Ph.D., Chief Scientific Officer, Black Diamond Therapeutics
Time: Poster Session A, Thursday, October 12, 12:30 pm-4:00 pm
Location/Poster #: Level 2, Exhibit Hall D, #A090

About BDTX-1535
BDTX-1535 is a brain-penetrant and potent MasterKey inhibitor of oncogenic mutations of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC), including families of intrinsic driver mutations and acquired resistance C797S mutation that result post-treatment with osimertinib. While current treatments for NSCLC target singular mutations, BDTX-1535 has the potential to address approximately 50 different mutations across a diverse group of patients in multiple lines of therapy. BDTX-1535 also has the potential to treat patients with glioblastoma multiforme (GBM) expressing EGFR alterations. The ongoing BDTX-1535 Phase 1 clinical trial is currently in dose expansion for NSCLC and dose escalation for GBM.