Adlai Nortye Ltd. & Nucleai awarded ESMO 2023 BEST Poster Award

SINGAPORE and NORTH BRUNSWICK, N.J. and HANGZHOU, China, Oct. 23, 2023 (GLOBE NEWSWIRE) -- Adlai Nortye Ltd. (NASDAQ: ANL) (the “Company” or “Adlai Nortye”), a global clinical-stage biotechnology company focused on innovative oncology drugs, and Nucleai, a pathology-based AI-powered biomarker discovery and diagnostics company, is pleased to announce today the receipt of the ESMO 2023 Best Poster Award for the Sunday, October 22, 2023 poster session with the presentation of the study “Utilizing H&E Images and Digital Pathology to Predict Response to Buparlisib in SCCHN”. The study assessed a novel methodology for identifying recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) patients that are likely to benefit from combination Buparlisib + paclitaxel treatment. The focus is to examine AI-based structuring and analyze H&E images to identify spatial features associated with clinical outcomes.

"Identifying potential candidates for Buparlisib + paclitaxel therapy among metastatic SCCHN patients is an important step to provide safer, more effective treatments, in order to realize positive health related outcomes, in a timely manner and to ultimately save lives. We are extremely pleased the study was recognized for its quality and success,” said Dr. Lars Birgerson, President & CMO of Adlai Nortye.

“We are excited to bring novel spatial biomarkers to the forefront of drug research and development, and look forward to further validating these findings in partnership with Adlai Nortye,” said Oscar Puig, VP Translational Medicine and Diagnostics at Nucleai.

The poster, #869P, was presented at the Head and Neck Cancers poster session on Sunday, October 22, 2023. The Best Poster Award was given at the conclusion of the Sunday Poster Session.

About Buparlisib (AN2025)
Buparlisib (AN2025) is an oral pan-PI3K inhibitor that targets all class I PI3K isoforms and is active in both hematologic malignancies and solid tumors. It is currently under development for metastatic SCCHN in the ongoing global Phase III BURAN study (NCT04338399).

About the BURAN study
The BURAN study is a randomized, open-label, multicenter phase III study to assess the treatment effect of once-daily buparlisib in combination with weekly paclitaxel compared to weekly paclitaxel alone in patients with recurrent or static head and neck squamous cell carcinoma (HNSCC) that have progressed after prior anti-PD-1/anti-PD-L1 monotherapy; prior anti-PD-1/anti-PD-L1 therapy in combination with platinum-d therapy; or after sequential treatment of anti-PD-1/anti-PD-L1 therapy, either prior to or post, platinum-based therapy.