Sangamo Therapeutics to Present Pre-Clinical Data Showcasing Its Epigenetic Regulation for Neurology and CAR-Treg Research at the 30th Annual Congress of the European Society of Gene & Cell Therapy (ESGCT)

Sangamo Therapeutics, Inc. (Nasdaq: SGMO), a genomic medicine company, today announced that the European Society of Gene & Cell Therapy (ESGCT) has accepted six Sangamo abstracts for presentation at the 30^th Annual Congress being held October 24-27, 2023, in-person in Brussels, Belgium. Presentations will focus on the progression of Sangamo’s pre-clinical programs, including data from its neurology epigenetic regulation programs, and advancements in the CAR-Treg pipeline.

“The data we are presenting at ESGCT reflect the important advances being made across our neurology and CAR-Treg pipelines,” said Jason Fontenot, Ph.D., Chief Scientific Officer at Sangamo. “We are excited to showcase these innovations, which reinforce the potential of our science to create transformative treatments for patients suffering with serious diseases.”

Data to be presented at the ESGCT Annual Congress include an oral presentation demonstrating how zinc finger activators (ZF-As) may be designed to potentially address neurodevelopmental disorders such as autism spectrum disorder and intellectual disability, for which limited therapeutic treatments currently exist. This presentation will show how ZF-As can be designed to restore normal gene and protein expression of SCN2A in vitro and in vivo. This will be accompanied by a poster presentation demonstrating Shank3 gene activation, mediated by ZF-As as a potential therapeutic approach for Phelan-McDermid syndrome. Both datasets originate from pre-clinical programs previously co-developed in partnership with Novartis.

Additional presentations at the ESGCT Annual Congress will unveil for the first time pre-clinical data showing that autologous MOG-CAR-Tregs may provide a long-lasting treatment option to potentially address the underlying cause of multiple sclerosis, as well as updated pre-clinical data evaluating IL23R-CAR-Tregs as a potentially effective treatment option to address inflammation for patients with Crohn’s disease. Data will also showcase our platform capability of efficient and durable epigenetic cell engineering using compact ZF-Repressors to target immune checkpoints with the potential to improve the anti-tumor activity of T cells in cancer therapy.