Latest Research Evaluating VASCEPA/VAZKEPA (icosapent ethyl) and Subgroups from the REDUCE-IT Landmark Outcomes Trial to be Presented at the American Heart Association (AHA) Scientific Sessions 2023

-- Additional Mechanistic Data on Eicosapentaenoic Acid (EPA) and Real-World Characteristics of Patients with Diabetes on IPE Also Featured at the Meeting --

DUBLIN, Ireland and BRIDGEWATER, N.J., Oct. 26, 2023 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ:AMRN) today announced new supported and/or funded research from the landmark REDUCE-IT cardiovascular outcomes trial on the effects of VASCEPA/VAZKEPA (icosapent ethyl) in a specific patient subgroups at increased risk of a cardiovascular (CV) event has been accepted for presentation at the American Heart Association (AHA) Scientific Sessions 2023, taking place November 11 – 13, 2023 in Philadelphia, PA.

The accepted abstracts include a presentation on the reduction in first and total CV events following treatment with VASCEPA/VAZKEPA in a unique, high-risk patient subgroup with a history of Metabolic Syndrome at baseline, but without diabetes. This subgroup was almost exclusively comprised of patients with established cardiovascular disease. In addition, data from mechanistic analyses will be presented providing additional insights into Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) and their differential effects in model lipid membranes as well as the effects of EPA on oxidation of Lp(a) enriched plasma. Lastly, an abstract describing the demographic/clinical characteristics of US patients taking icosapent ethyl, focusing on those with diabetes, will also be presented. These and other new findings will be presented by a variety of international academic collaborators based on research or analyses supported by Amarin.

Nabil Abadir, MB. CH.B., SVP, Chief Medical Officer, and Head of Global Medical Affairs at Amarin, commented on the data being presented at the meeting, stating, "The data being presented at Scientific Sessions continue to further validate the overall results of the REDUCE-IT trial and the added value of VASCEPA/VAZKEPA for patients. With these data we now have more insights into patients with a history of Metabolic Syndrome at baseline, including those secondary prevention patients with established cardiovascular disease, a patient group particularly at high-risk of having another cardiovascular event. Additionally, we are pleased to support data being featured at the meeting highlighting the characteristics of patients with diabetes who were put on IPE in a real world setting as well as data that continue to illuminate the mechanism of action underlying the icosapent ethyl molecule."